Yazar "Deniz, Muzaffer Serdar" seçeneğine göre listele

Listeleniyor 1 - 6 / 6
  • Küçük Resim Yok
    Öğe
    Examining the impact of several factors including COVID-19 on thyroid fine-needle aspiration biopsy
    (Wiley, 2023) Deniz, Muzaffer Serdar; Dindar, Merve
    Objective: The study explores various factors, including coronavirus disease 2019 (COVID-19) history and vaccination status, that influence the classification value of ultrasonography-guided thyroid fine needle aspiration biopsy (TFNAB) by comparing non-diagnostic (Bethesda-I) and diagnostic (Bethesda II-VI) results. Methods: We conducted a retrospective observational study in a high-volume tertiary care center involving patients who underwent TFNAB from November 2022 to April 2023. The study retrospectively analyzed the cytopathology of 482 thyroid nodules. Patients were categorized into non-diagnostic (n = 136) and Diagnostic groups (n = 346) based on TFNAB. A comprehensive set of parameters was examined, including demographic, anthropometric and clinical data, thyroid ultrasonography findings, COVID-19 history and immunization status. Results: The mean age was 55.1 +/- 12.1 years in the non-diagnostic group and 53.5 +/- 13 years in the Diagnostic group (p = .223). 75.7% (n = 103) of the non-Diagnostic group and 82.9% (n = 287) of the Diagnostic group were male (p = .070). The mean nodule longitudinal diameter of the Diagnostic group was significantly higher than that of the non-diagnostic group (p = .015). The TIRADS score of the nodules showed a statistical difference between the groups (p = .048). The groups had no significant differences regarding other ultrasonographic parameters and COVID-19-related variables. Conclusion: It can be assumed that when the longitudinal diameter of the thyroid nodule is small and in TIRADS categories other than the TIRADS3 category, TFNAB is less likely to be diagnostic. However, future research may be needed to confirm these findings and uncover any long-term effects of COVID-19 or vaccines on thyroid nodule diagnostics.
  • Küçük Resim Yok
    Öğe
    The impact of anthropometric parameters and sonographic characteristics on the choice of biopsy method for thyroid nodules: Fine-needle aspiration versus non-aspiration biopsy
    (Scientific Scholar Llc, 2024) Deniz, Muzaffer Serdar; Ozder, Nuriye; Narli, Zubeyde Ilke
    Objective: The accurate diagnosis of thyroid nodules is crucial for effective management and the detection of malignancy. Fine-needle aspiration biopsy (FNAB) and fine-needle non-aspiration biopsy (FNNAB) are widely used techniques for evaluating thyroid nodules. In this study, we aimed to investigate the impact of anthropometric parameters and sonographic characteristics on the choice between FNAB and FNNAB in terms of diagnostic yield. Material and Methods: This retrospective and cross-sectional analysis involved 188 cases with a total of 225 thyroid nodules. Each nodule initially underwent either FNAB or FNNAB and if the initial biopsy did not yield a diagnostic result, the nodule was re-biopsied using the alternate technique. Ultrasound was used to evaluate the nodules, with a focus on echogenicity, calcifications, size, vascularity, and the presence of a halo sign. Both FNAB and FNNAB were performed using a 25-gauge needle, with the only difference being the application of suction. Results: FNAB demonstrated a higher diagnostic rate for nodules with a taller-than-wide shape (anteroposteriorto-transverse ratio >= 1), nodules sized 10-40 mm, nodules with volumes <0.5 cc, and hypoechoic nodules (P < 0.001 for all). FNAB also outperformed FNNAB in the assessment of the right-sided, inferior, and posterior nodules (P P < 0.001), nodules with and without calcification (P P = 0.041 and P = 0.020, respectively), and nodules with type 1 and type 2 vascularity patterns (P P = 0.006 and P = 0.017, respectively). FNAB was effective in obese individuals (Body mass index >= 40 kg/m(2)), males with a waist circumference of <94 cm, females with a waist circumference of >= 80 cm, and females with a neck circumference of >= 34 cm (P = 0.011, P = 0.044, P = 0.029, and P = 0.008, respectively). Conclusion: Anthropometric parameters and sonographic characteristics influenced the diagnostic yield of FNAB and FNNAB, with FNAB generally demonstrating superior results. Given the importance of obtaining an accurate diagnostic result from fine-needle biopsy, clinicians should consider both the sonographic features of the nodule and the anthropometric measurements of the patient when selecting a biopsy technique.
  • Küçük Resim Yok
    Öğe
    Investigation of pre-operative demographic, biochemical, sonographic and cytopathological findings in low-risk thyroid neoplasms
    (Wiley, 2023) Deniz, Muzaffer Serdar; Ozdemir, Didem; Imga, Narin Nasiroglu; Baser, Huesniye; Seyrek, Fatma Neslihan Cuhaci; Altinboga, Ayseguel Aksoy; Topaloglu, Oya
    ObjectiveThe present article analyses pre-operative demographic, biochemical, sonographic and histopathological characteristics of low-risk thyroid neoplasms (LRTNs), with a focus on four subgroups, well-differentiated carcinoma-not otherwise specified (WDC-NOS), non-invasive follicular thyroid neoplasm with papillary like nuclear features (NIFTP), well-differentiated tumours of uncertain malignant potential (WDT-UMP) and follicular tumour of uncertain malignant potential (FT-UMP).MethodsThe study retrospectively analyzed the histopathology of 2453 malignant thyroids and the final analyses included 99 cases diagnosed with LRTNs. The demographic and clinical features, pre-operative thyroid function, ultrasonography results, cytopathology results, histopathology results and prognostic classifications were assessed.ResultsThe groups were similar demographic characteristics and the majority of clinical data, including comorbidities, thyroid function tests, thyroid cancer/neck radiotherapy history. NIFTPs represented 69.7% of all LRTNs. All (100%) WDT-UMPs had solitary nodules. Index nodule volume differed among the groups (p = .036), it was the lowest in WDC-NOS [0.68 (0.63-0.72 cc)] and highest in FT-UMP [12.6 (0.5-64 cc)]. Echogenicity findings were similar. Index nodule TIRADS demonstrated a significant difference (p = .021) but index nodule halo sign and BETHESDA scores were similar in all groups. The diameter, localisation and multicentric structure of LRTNs were again similar for all groups. Finally, prognostic scores suggested similar outcomes in all groups.ConclusionThe majority of LRTNs were NIFTPs in our population and all WDT-UMPs were solitary lesions. Index nodule volume was the most essential discriminating sonographic finding but further research must be performed before discriminatory potential can be described.
  • Küçük Resim Yok
    Öğe
    Novel diagnostic parameters in the differentiation of isolated iron deficiency and iron deficiency accompanying chronic disease before progressing anemia
    (2023) Deniz, Muzaffer Serdar; Karaahmetoglu, Selma
    Objectives: The study aimed to investigate the patients with isolated iron deficiency (IID) and chronic disease-ac- companied iron deficiency (CDID) and to analyze the predictive values of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) that can help us to distinguish IID from CDID. Methods: Three hundred patients joined the present cross-sectional thesis study. Half had chronic diseases+ID (with- out anemia) called as CDID, while the other half did not have any chronic disease or anemia called IID in the text. Labo- ratory parameters and patient histories were obtained from the automation system and analyzed. Results: The CDID was associated with ferritin increase (Odds Ratio [OR]=1.123; 95% Confidence Intervals [CI]=1.084– 1.165). Increased sedimentation was associated with an increased risk of having a CDID (OR=1.023; 95% CI = 1.003– 1.045). Ferritin showed a predictive potential for CDID with 67.2% specificity and 71.1% sensitivity at a 12.1 cutoff value (Auc:0.781; p<0.0001). NLR was the second strong predictor of CDID against IID, with 64.1% specificity and 63.5% sensitivity at a 2.09 cutoff (Auc:0.629; p<0.0001). PLR had no significance for discrimination of CDID and IID. Conclusion: NLR can provide diagnostic support like ferritin in predicting CDID against IID and benefit physicians in the clinical use of differentiation, unlike PLR.
  • Küçük Resim Yok
    Öğe
    A novel proportional index to differentiate between demographically and clinically matched cases with papillary thyroid carcinoma or non-cancerous nodule: PLR-to-PDW ratio
    (E-Century Publishing Corp, 2023) Deniz, Muzaffer Serdar
    Objectives: To analyze PLR-to-PDW ratio as a novel diagnostic index in the discrimination of benign thyroid nodules (BTN) and papillary thyroid carcinoma (PTC), and to analyze the discriminatory power of a novel index (platelet-to-lymphocyte ratio divided by platelet distribution width: PLR-to-PDW ratio) in comparison with previously-examined inflammatory indices including neutrophil-to-lymphocyte ratio (NLR), PLR, prognostic nutritional index (PNI), systemic inflammation index (SII), and systemic inflammatory response index (SIRI). Methods: This cross-sectional retrospective research included 459 demographically and clinically-matched participants who underwent thyroid examination with ultrasonography and fine-needle aspiration biopsy. NLR, PLR, SII, SIRI and PLR-to-PDW were calculated manually from complete blood count results. PNI was calculated as albumin (g/dL) + 5 x lymphocyte count. Results: Among the inflammatory indices, NLR, PLR and PLR-to-PDW ratio were significantly higher in patients with PTC compared to those with BTN. Logistic regression showed that NLR (OR: 1.414, P=0.0083), PLR (OR: 1.537, P=0.0065) and PLR-to-PDW (OR: 2.054, P=0.0016) were independently associated with a greater likelihood of PTC. Among the previously-examined indices, PLR had the best discriminatory performance with 73.4% sensitivity and 70.8% specificity for a > 149.6 cut-off (AUC: 0.786, P=0.0011). However, the novel ratio examined in this study, PLRto-PDW, had better predictive value to distinguish PTC cases from BTN with 78.1% sensitivity and 73.7% specificity at a > 9.11 cut-off (AUC: 0.827, P=0.0001). Conclusions: The presently proposed PLR-to-PDW ratio exhibited the highest diagnostic discriminatory power compared to other inflammatory indices, indicating a relatively better utility to distinguish cases with PTC from those with BTN.
  • Küçük Resim Yok
    Öğe