Investigation of pre-operative demographic, biochemical, sonographic and cytopathological findings in low-risk thyroid neoplasms
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
ObjectiveThe present article analyses pre-operative demographic, biochemical, sonographic and histopathological characteristics of low-risk thyroid neoplasms (LRTNs), with a focus on four subgroups, well-differentiated carcinoma-not otherwise specified (WDC-NOS), non-invasive follicular thyroid neoplasm with papillary like nuclear features (NIFTP), well-differentiated tumours of uncertain malignant potential (WDT-UMP) and follicular tumour of uncertain malignant potential (FT-UMP).MethodsThe study retrospectively analyzed the histopathology of 2453 malignant thyroids and the final analyses included 99 cases diagnosed with LRTNs. The demographic and clinical features, pre-operative thyroid function, ultrasonography results, cytopathology results, histopathology results and prognostic classifications were assessed.ResultsThe groups were similar demographic characteristics and the majority of clinical data, including comorbidities, thyroid function tests, thyroid cancer/neck radiotherapy history. NIFTPs represented 69.7% of all LRTNs. All (100%) WDT-UMPs had solitary nodules. Index nodule volume differed among the groups (p = .036), it was the lowest in WDC-NOS [0.68 (0.63-0.72 cc)] and highest in FT-UMP [12.6 (0.5-64 cc)]. Echogenicity findings were similar. Index nodule TIRADS demonstrated a significant difference (p = .021) but index nodule halo sign and BETHESDA scores were similar in all groups. The diameter, localisation and multicentric structure of LRTNs were again similar for all groups. Finally, prognostic scores suggested similar outcomes in all groups.ConclusionThe majority of LRTNs were NIFTPs in our population and all WDT-UMPs were solitary lesions. Index nodule volume was the most essential discriminating sonographic finding but further research must be performed before discriminatory potential can be described.
Açıklama
Anahtar Kelimeler
follicular tumour of uncertain malignant potential, low-risk thyroid neoplasms, non-invasive follicular thyroid neoplasm with papillary-like nuclear features, well-differentiated carcinoma-not otherwise specified, well-differentiated tumours of uncertain malignant potential
Kaynak
Clinical Endocrinology
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
99
Sayı
5
