Yazar "Deniz, Omur Gulsum" seçeneğine göre listele

Listeleniyor 1 - 1 / 1
  • Küçük Resim Yok
    Öğe
    An investigation of the effectiveness of atmospheric pressure cold plasma on sciatic nerve injury in rats
    (Via Medica, 2024-05-13) Yilmaz, Nesibe; Deniz, Omur Gulsum; Secgin, Seyda; Secgin, Yusuf; Bozduman, Ferhat
    Background: The aim of this study was to evaluate the efficacy of atmospheric pressure cold plasma jet and plasma activated medium (PAM) on sciatic nerve injury (SNI). Materials and methods: Rats were divided into 6 groups (n = 10); group 1 (sham), group 2 (SNI), group 3 (SNI + atmospheric pressure cold plasma jet 5 min), group 4 (SNI + atmospheric pressure cold plasma jet 10 min), group 5 (SNI + PAM 5 min), and group 6 (SNI + PAM 10 min). On days 1, 8, 15, and 22 of the study, atmospheric pressure cold plasma jet was applied to rats in groups 3 and 4, and PAM was applied to rats in groups 5 and 6. A hot plate test was applied to all rats on the same days. On day 28, the experiment was terminated, and sciatic nerve tissues were removed for histopathological evaluation. Results: According to the 4-week average of the hot plate tests, a significant relationship was found between group 2 and group 4 and group 6 (p < 0.05). When evaluated within each week, significant differences were found between group 2 and group 4 in week 1, between group 2 and group 5 and group 6 in week 2, between group 2 and group 4 in week 3, and between group 2 and group 4 and group 6 in week 4 (p < 0.05). As a result of histopathological analysis, except for the control group, the other groups had similar characteristics in terms of axonal degeneration, periaxonal swelling, and axon density. Conclusions: As a result of our study, we found that plasma application showed an improvement in the duration of the hot plate test but did not show any improvement histopathologically.