An investigation of the effectiveness of atmospheric pressure cold plasma on sciatic nerve injury in rats
Küçük Resim Yok
Tarih
2024-05-13
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Via Medica
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: The aim of this study was to evaluate the efficacy of atmospheric pressure cold plasma jet and plasma activated medium (PAM) on sciatic nerve injury (SNI). Materials and methods: Rats were divided into 6 groups (n = 10); group 1 (sham), group 2 (SNI), group 3 (SNI + atmospheric pressure cold plasma jet 5 min), group 4 (SNI + atmospheric pressure cold plasma jet 10 min), group 5 (SNI + PAM 5 min), and group 6 (SNI + PAM 10 min). On days 1, 8, 15, and 22 of the study, atmospheric pressure cold plasma jet was applied to rats in groups 3 and 4, and PAM was applied to rats in groups 5 and 6. A hot plate test was applied to all rats on the same days. On day 28, the experiment was terminated, and sciatic nerve tissues were removed for histopathological evaluation. Results: According to the 4-week average of the hot plate tests, a significant relationship was found between group 2 and group 4 and group 6 (p < 0.05). When evaluated within each week, significant differences were found between group 2 and group 4 in week 1, between group 2 and group 5 and group 6 in week 2, between group 2 and group 4 in week 3, and between group 2 and group 4 and group 6 in week 4 (p < 0.05). As a result of histopathological analysis, except for the control group, the other groups had similar characteristics in terms of axonal degeneration, periaxonal swelling, and axon density. Conclusions: As a result of our study, we found that plasma application showed an improvement in the duration of the hot plate test but did not show any improvement histopathologically.
Açıklama
Anahtar Kelimeler
atmospheric pressure cold plasma jet, histopathology, hot plate test, plasma-activated media, sciatic injury
Kaynak
Folia Morphologica (Poland)
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
83
Sayı
4
Künye
Yılmaz, N., Deniz, O. G., Secgin, S., Secgin, Y., & Bozduman, F. (2024). An investigation of the effectiveness of atmospheric pressure cold plasma on sciatic nerve injury in rats. Folia morphologica, 83(4), 813–822. https://doi.org/10.5603/fm.100019
