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    Evaluating the Role of Antibiotic Use in the Development of Cow's Milk Protein Allergy within the First Year of Life among the Patients Treated in the NICU
    (Mashhad Univ Med Sciences, 2022) Ekmen, Sadrettin; Sevinc, Eylem; Ozkul, Hatice; Derme, Turan
    Background: It has been reported that the incidence of Cow's Milk Protein Allergy (CMPA) has increased in recent years, especially among infants in the first year of life. It is thought that the use of antibiotics may trigger the development of CMPA by causing intestinal dysbiosis and altering immune response, and thus, it may be a factor responsible for the supposed increase. The relationship between antibiotic use and the development of CMPA has been evaluated in very few studies in the literature. Thus, this study aimed to evaluate whether CMPA development is associated with antibiotic use during pregnancy or neonatal period. Method: During the study period, 1120 babies were followed up in our NICU, 975 of whom met the inclusion criteria. The development of CMPA within the first year of life was evaluated among the infants hospitalized and followed up in the Neonatal Intensive Care Unit (NICU) of Karabuk University, Faculty of Medicine, Training and Research Hospital, between January 1, 2017 and October 30, 2020. Results: The neonates whose mothers had used antibiotics received mechanical ventilation treatment at a significantly higher frequency (p = 0.042). There was no significant difference in the frequency of CMPA development between the infants of mothers with and without antibiotic use (p = 0.533). Compared to the babies who did not use antibiotics, the gestational week, birth weight, 1st and 5th minute APGAR scores of the babies who used antibiotics were significantly lower, and their frequency of mechanical ventilation treatment was significantly higher (p<0.001). There was no significant difference between infants who used and did not use antibiotics in terms of the frequency of CMPA development (p = 0.150). In general, it was found that the use of antenatal and postnatal antibiotics did not increase the development of CMPA. Conclusion: The data of our study contradicts the two study of which previously associated maternal and infant antibiotic use with the development of CMPA. This contradiction suggests that the aetiology of CMPA is multifactorial and more studies are needed to elucidate the antibiotic-CMPA relationship.
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    Evaluation of land transportation of newborns in Türkiye
    (2022) Ekmen, Sadrettin; Derme, Turan
    Aim: In our country, the number of Neonatal Intensive Care Units (NICUs) and the quality of service has considerably increased during the last two decades. However, im- provements in the safe transportation of newborns are not at the same rate, and there are many problems that need to be solved. Appropriate transport conditions should be pro- vided to reduce neonatal mortality and morbidity. In this study, our aim was to present transportation problems in an understandable manner, to reveal solutions proposed by the addressees of these problems, and to reduce transport-related neonatal mortality and morbidity by drawing attention to this issue. Materials and Methods: As a cross-sectional descriptive study, we attempted to reach as many physicians as possible who played a relevant role in neonatal transport and invited them to respond to a Google Forms questionnaire concerning neonatal transport problems, between the 10th and 30th of April, 2022, and their responses were recorded. Results: A total of 90 participants responded to the questionnaire. Neonatal specialists were the group with the highest response rate of 54.4%. Most of the participants were employed at University Hospitals or Training and Research Hospitals (69.7%). The most frequently used transport system was the on-duty team referred by the emergency call (112) center (84%). The participants reported that they frequently encountered unde- sirable events during transport, and that the transport team’s approach to these events was inadequate. The solution proposal chosen most often was found to be: ‘supplying vehicles with equipment similar to those used in NICUs throughout the various regions of our country with respect to population density, and ensuring that personnel employed in these vehicles are only involved in the transportation of newborns’. Conclusion: In our country, improvements in neonatal transport are urgently needed to reduce neonatal mortality and morbidity.