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Öğe Clinical and Laboratory Effects of Foodborne Illness in Children(Mary Ann Liebert, Inc, 2024) Deniz, Yusuf; Ekmen, Sadrettin; Dogan, Erkan; Calis, Seyda OzdenThe World Health Organization estimates that 31 foodborne pathogen account for 600 million cases of illness annually. This study, conducted in a pediatric emergency department in Turkey, addresses the limited research on pediatric foodborne diseases (FD) in the country, exposing a significant knowledge gap. Analyzing 17,091 pediatric cases, 106 FD cases were identified, predominantly affecting boys (94.3%) with an average age of 7.65 +/- 6.51 years. Remarkably, no patients required pediatric intensive care admission, and no mortalities were recorded. Hyponatremia emerged as a prevalent electrolyte disorder in pediatric FD, while hyperkalemia was notably observed in children under 5. The study emphasizes the severity of FD in children under 5, reflected in longer hospital stays, underscoring the urgent need for targeted interventions and improved detection methods in pediatric FD.Öğe Evaluating the Role of Antibiotic Use in the Development of Cow's Milk Protein Allergy within the First Year of Life among the Patients Treated in the NICU(Mashhad Univ Med Sciences, 2022) Ekmen, Sadrettin; Sevinc, Eylem; Ozkul, Hatice; Derme, TuranBackground: It has been reported that the incidence of Cow's Milk Protein Allergy (CMPA) has increased in recent years, especially among infants in the first year of life. It is thought that the use of antibiotics may trigger the development of CMPA by causing intestinal dysbiosis and altering immune response, and thus, it may be a factor responsible for the supposed increase. The relationship between antibiotic use and the development of CMPA has been evaluated in very few studies in the literature. Thus, this study aimed to evaluate whether CMPA development is associated with antibiotic use during pregnancy or neonatal period. Method: During the study period, 1120 babies were followed up in our NICU, 975 of whom met the inclusion criteria. The development of CMPA within the first year of life was evaluated among the infants hospitalized and followed up in the Neonatal Intensive Care Unit (NICU) of Karabuk University, Faculty of Medicine, Training and Research Hospital, between January 1, 2017 and October 30, 2020. Results: The neonates whose mothers had used antibiotics received mechanical ventilation treatment at a significantly higher frequency (p = 0.042). There was no significant difference in the frequency of CMPA development between the infants of mothers with and without antibiotic use (p = 0.533). Compared to the babies who did not use antibiotics, the gestational week, birth weight, 1st and 5th minute APGAR scores of the babies who used antibiotics were significantly lower, and their frequency of mechanical ventilation treatment was significantly higher (p<0.001). There was no significant difference between infants who used and did not use antibiotics in terms of the frequency of CMPA development (p = 0.150). In general, it was found that the use of antenatal and postnatal antibiotics did not increase the development of CMPA. Conclusion: The data of our study contradicts the two study of which previously associated maternal and infant antibiotic use with the development of CMPA. This contradiction suggests that the aetiology of CMPA is multifactorial and more studies are needed to elucidate the antibiotic-CMPA relationship.Öğe Evaluation of amplitude-integrated EEG use in the neonatal intensive care unit(Bayrakol Medical Publisher, 2022) Ekmen, Sadrettin; Deniz, YusufAim: Amplitude-integrated electroencephalogram (aEEG) is widely used in neonatal intensive care units (NICU), as it is easier to interpret than conventional EEG and does not prevent invasive procedures in infants. Although it is frequently used in the diagnosis and follow-up of Hypoxic Ischemic Encephalopathy (HIE) and neonatal convulsions developing after perinatal asphyxia, the relationship between neurological examination, aEEG and conventional EEG (cEEG) is still not fully understood. Material and Methods: This study was carried out by retrospective evaluation of the patient's files and aEEG records of 59 infants who were followed up with aEEG in the Neonatal Intensive Care Unit of Karabuk University Training and Research Hospital between January 1, 2020 and January 31, 2022. One infant who was beyond the neonatal period was not included in the analysis. The data of 38 infants with perinatal asphyxia and 20 infants who were prediagnosed with convulsions were evaluated. Results: aEEG results of the infants diagnosed with perinatal asphyxia were found to be highly consistent with neurological examination in the early and late periods (84.2%). However, convulsion was detected in aEEG only in 20% of 20 infants with abnormal movements clinically suggestive of convulsions. Discussion: Our study revealed that the use of aEEG is beneficial in infants who develop HIE after perinatal asphyxia but its benefit in the diagnosis and follow-up of neonatal seizures is not clear. We believe that the use of multi-channel aEEG and/or the use of aEEG together with conventional EEG in neonatal convulsion follow-up will provide more useful information.Öğe Evaluation of Gentamicin Ototoxicity in Newborn Infants: A Retrospective Observational Study(Mashhad Univ Med Sciences, 2021) Ekmen, Sadrettin; Dogan, ErkanBackground The main purpose of this study was to demonstrate the effect of gentamicin on hearing tests in newborns treated with gentamicin in our NICU, and to contribute to the selection of antibiotics more consciously. Materials and Methods: Infants who Nvere hospitalized and followed up in the NICU of Karabuk University Medical Faculty Hospital, Karabuk, Turkey, between December 2019 and November 2020 were included in our study. During the study period, 331 infants hospitalized in the NICU and meeting the inclusion criteria were included.The infants were divided into two groups, with and without gentamicin treatment, and their demographic characteristics, respiratory support treatment and hearing test results were retrospectively analyzed and the results were compared. Automated auditory brainstem response (ABR) was used for newborn hearing screening at discharge. Results: Demographically, maternal age and birth weight were found to be significantly lower in gentamicin patients. Delivery method and gestational age were similar between the two groups. While the rates of passing the first test in the ABR screening were higher in the gentamicin group (p=0.051), only 1 infant in the same group failed the ABR second screening. This infant was 34 weeks old, a fraternal twin born at 2200 g, and no hearing loss was found in the infant's twin. When the anamnesis was observed in detail, the infants' uncle manifested a history of hospitalization for the treatment of urinary tract infection in his youth. In the meantime, his history of amikacin treatment and consequent experience of sensorineural hearing loss was revealed. Conclusion We concluded that gentamicin does not affect the hearing test when it is not used in the short-term (5-7 days), extended dosing intervals (24-48 hours), and ototoxic drugs such as loop diuretics.Öğe Evaluation of land transportation of newborns in Türkiye(2022) Ekmen, Sadrettin; Derme, TuranAim: In our country, the number of Neonatal Intensive Care Units (NICUs) and the quality of service has considerably increased during the last two decades. However, im- provements in the safe transportation of newborns are not at the same rate, and there are many problems that need to be solved. Appropriate transport conditions should be pro- vided to reduce neonatal mortality and morbidity. In this study, our aim was to present transportation problems in an understandable manner, to reveal solutions proposed by the addressees of these problems, and to reduce transport-related neonatal mortality and morbidity by drawing attention to this issue. Materials and Methods: As a cross-sectional descriptive study, we attempted to reach as many physicians as possible who played a relevant role in neonatal transport and invited them to respond to a Google Forms questionnaire concerning neonatal transport problems, between the 10th and 30th of April, 2022, and their responses were recorded. Results: A total of 90 participants responded to the questionnaire. Neonatal specialists were the group with the highest response rate of 54.4%. Most of the participants were employed at University Hospitals or Training and Research Hospitals (69.7%). The most frequently used transport system was the on-duty team referred by the emergency call (112) center (84%). The participants reported that they frequently encountered unde- sirable events during transport, and that the transport team’s approach to these events was inadequate. The solution proposal chosen most often was found to be: ‘supplying vehicles with equipment similar to those used in NICUs throughout the various regions of our country with respect to population density, and ensuring that personnel employed in these vehicles are only involved in the transportation of newborns’. Conclusion: In our country, improvements in neonatal transport are urgently needed to reduce neonatal mortality and morbidity.Öğe Prediction of the Course of Transient Tachypnea of the Newborn by Blood Laboratory Parameters at the Time of Admission(Kowsar Corp, 2021) Ekmen, Sadrettin; Dogan, ErkanBackground: Transient tachypnea of the newborn (TTN) is a common but mild respiratory problem seen in late preterm and term newborns. However, it may sometimes cause severe morbidity. Objectives: Therefore, biomarkers that can predict TTN severity may aid the clinician in determining the need for intensive care. Our aim was to identify whether blood gases and complete blood count parameters could be utilized to predict the severity of TTN.s Methods: We retrospectively examined the medical records of newborns (> 37 weeks gestation, > 2000 grams) diagnosed with TTN who were hospitalized in the Neonatal Intensive Care Unit (NICU) of Karabuk University Faculty of Medicine, Training and Research Hospital, Karabuk/Turkey between June 2019 and June 2020. Patients were grouped according to the length of stay in the NICU. Group 1 included patients that did not require NICU monitoring after 48 hours, and group 2 included patients who continued to require NICU monitoring after 48 hours. Blood gases and complete blood count parameters were compared between the two groups. Results: During the study period, 91 newborns were hospitalized in the NICU due to respiratory distress. Thirty-nine patients who did not meet the inclusion criteria were excluded. Gestational age and birth weight were significantly lower in group 2 (P < 0.05). There were no significant differences between the groups in terms of leukocyte count, hemoglobin level, mean platelet volume (MPV), and platelet count. Partial carbon dioxide pressure (PCO2) was significantly elevated, and base excess (BE) was significantly greater in group 2. Conclusions: We determined a relationship between a prolonged stay in NICU and the levels of PCO2 and BE among patients hospitalized with a diagnosis of TTN. Therefore, PCO2 and BE values may be valuable to determine the prognosis of TTN in the early period. Despite being one of the most common causes of intensive care admission in the newborn population, there is limited data on the diagnosis, treatment, and prognosis of TTN; thus, we believe that our results will shed light on this problem.Öğe Rotavirus Infections: A 2-Year Comprehensive Review in Admitted Pediastric Patients Amid Conflicting National Policies(Mary Ann Liebert, Inc, 2024) Deniz, Yusuf; Demircioglu, Burak; Kuter-Emeklioglu, Irem; Ekmen, Sadrettin; Sevinc, Eylem; Dogan, ErkanHighlighting rotavirus (RV) as a significant food and waterborne pathogen, particularly affecting infants and children, causing serious gastrointestinal infections and dehydration, is important. It should be noted that there are significant debates regarding the effectiveness and outcomes of RV vaccination. In contrast to Turkey's nonmandatory vaccination policy, many developed countries implement mandatory vaccination policies, raising questions about their impact on disease prevalence and healthcare expenditures. Our study aims to comprehensively understand RV infections in Turkey and compare them with countries that have mandatory vaccination policies. We found similar, and even better, hospitalization rates, length of hospital stays, and laboratory parameters demonstrating the effectiveness of Turkey's independent vaccination approach. These findings contribute valuable insights to global vaccination strategies and disease control.Öğe SLC26A3 mutation in Turkish neonate and her sibling with congenital chloride diarrhea(Turkish Pediatrics Assoc, 2020) Dogan, Erkan; Sevinc, Eylem; Goktas, Mehmet Akif; Ekmen, Sadrettin; Yildiz, NihalCongenital chloride diarrhea is a rare cause of severe infantile diarrhea with excessive chloride excretion. Mutations in the SLC26A3 gene cause congenital chloride diarrhea. It generally becomes apparent in the neonatal period and is characterized by electrolyte imbalances, metabolic alkalosis, and failure to thrive. The diagnosis of congenital chloride diarrhea is based on detecting excessive chloride in the stool (90 mmol/L). We report a Turkish neonate with congenital chloride diarrhea whose sibling had the same disease. The newborn was born by cesarean delivery. Diarrhea, vomiting, and weight loss started soon after birth. She was diagnosed as having congenital chloride diarrhea based on its typical clinical signs and a high concentration of stool chloride and was confirmed by genetic analysis. She was treated by means of salt supplementations and lansoprazole. Family history may play an important role in the early diagnosis because the disease is inherited autosomal recessively.
