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    In vitro antioxidant activity and carbonic anhydrase inhibitory features of ferula communis extracts
    (2021) Aydın, Fatma Gülruy; Kahraman, Zeynep Aleyna; Türkoğlu, Emir Alper; Kuzu, Müslüm; Severoğlu, Zeki
    Carbonic anhydrases (CAs; EC 4.2.1.1) are essential family of metalloenzymes which catalyze the interconversion between carbon dioxide (CO2) and bicarbonate (HCO3-) in all organisms of three-domains of life. Huge amounts of attempts related to catalytic activity of CAs have been widely expanded to treat many clinical diseases. This study aimed to determine in-vitro antioxidant activities and human CA I (hCA I) and II (hCA II) inhibitory properties of Ferula communis extracts. Among all extracts of F. communis, the hexane extract has showed the best inhibitory profile on hCA I and II with IC50 values 8.68 µg/mL and 28 µg/mL and Ki values 2.026 µg/mL and 11.6 µg/mL, respectively. All extracts showed mild to moderate antioxidant activity. According to the results of DPPH assay, ethanol-water extract showed the highest activity with IC50: 0.1128±0.0066 value. Chloroform extract showed the highest activity on CUPRAC assay with the value of 1.305±0.037 mM Trolox equivalent/mg extract. However, further analytical, in-vivo and clinical studies are needed to confirm the activities of F. communis.
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    In vitro carbonic anhydrase inhibitory effects of the extracts of satureja cuneifolia
    (2021) Aydın, Fatma Gülruy; Türkoğlu, Emir Alper; Kuzu, Müslüm; Taşkın, Turgut
    Carbonic anhydrases catalyze the interconversion between carbon dioxide and bicarbonate. Carbonicanhydrase inhibition has therapeutic importance and there are many drugs which use this mechanism.Carbonic anhydrase inhibitors are used as diuretic, antiglaucoma, antitumor and antiepileptic agents. As analternative for synthetic chemicals with strong side effects, natural products have gained popularity in therecent years. In this study, Satureja cuneifolia, a medicinal plant used as folk medicine, was investigated for itsinhibition effects on carbonic anhydrase I and II enzymes. Four different extracts were obtained withmaceration method and three different solvents were used. The results have shown that methanol extracts ofSatureja cuneifolia has the strongest inhibition activity on the enzymes with the IC50 values of 31 µg/mL for hCAI and 12 µg/mL for hCA II. Further purification and analytical studies will be needed to obtain the active naturalmolecules and their potential for pharma and food industries.