In vitro antioxidant activity and carbonic anhydrase inhibitory features of ferula communis extracts
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Carbonic anhydrases (CAs; EC 4.2.1.1) are essential family of metalloenzymes which catalyze the interconversion between carbon dioxide (CO2) and bicarbonate (HCO3-) in all organisms of three-domains of life. Huge amounts of attempts related to catalytic activity of CAs have been widely expanded to treat many clinical diseases. This study aimed to determine in-vitro antioxidant activities and human CA I (hCA I) and II (hCA II) inhibitory properties of Ferula communis extracts. Among all extracts of F. communis, the hexane extract has showed the best inhibitory profile on hCA I and II with IC50 values 8.68 µg/mL and 28 µg/mL and Ki values 2.026 µg/mL and 11.6 µg/mL, respectively. All extracts showed mild to moderate antioxidant activity. According to the results of DPPH assay, ethanol-water extract showed the highest activity with IC50: 0.1128±0.0066 value. Chloroform extract showed the highest activity on CUPRAC assay with the value of 1.305±0.037 mM Trolox equivalent/mg extract. However, further analytical, in-vivo and clinical studies are needed to confirm the activities of F. communis.
Açıklama
Anahtar Kelimeler
Kaynak
International Journal of Agriculture, Environment and Food Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
5
Sayı
4
