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    Evaluation of Antibacterial Activity of Calcium Phosphates Based Bone Cements for Biomedical Applications
    (Natl Inform & Document Centre, 2022) Alshemary, Ammar Z.; Sarsik, Betul; Salman, Nader A.; Sahin, Sitem Merve; Sahin, Mehmet Murat; Muhammed, Yasser
    In orthopedics and traumatology surgeries, the repair of bone deformities is a concern. Pure and Cobalt (Co) doped Calcium phosphate (CaP) cements were successfully prepared in this study. The particles that had been manufactured were characterized. Three different methods were used to study the structure of the materials: X-ray powder diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and Scanning electron microscope (SEM). The lattice characteristics, degree of crystallinity, and particle size of pure CaP bone cement were reduced dramatically with the incorporation of Co2+ ions. The functional groups of CaP bone cements were detected via the FTIR technique. Antibacterial properties of pure and Co doped CaP bone cement were evaluated qualitatively against Escherichia coli (E. Coli, gram -), Methicillin-sensitive Staphylococcus aureus (MSSA, gram +). Methicillin-resistant Staphylococcus aureus (MRSA, gram +), Methicillin-resistant coagulase-negative staphylococci (MR-CoNS, gram +), and Pseudomonas aeruginosa (P. aeruginosa, gram -) bacteria for 24 h at 37 degrees C. After analyzing the data, it was found that the inclusion of Co2+ ions inhibited the growth of E. coli and MSSA bacteria. Antibacterial bone cements are potential material for preventing infection-related bone healing failures.
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    MESOPOROUS SULPHATE DOPED HYDROXYAPATITE NANOPARTICLES FOR CONTROLLED RELEASE OF PROTEINS
    (Univ Chemistry & Technology, Prague, 2022) Alshemary, Ammar Z.; Muhammed, Yasser; Salman, Nader A.; Motameni, Ali; Gurbuz, Riza
    The purpose of this study is to synthesize and characterize the mesoporous nanostructure of Hydroxyapatite (HA), evaluate the impact of the addition of sulphate ions (SO42-) on the microstructure properties of HA, and assess the ability of the prepared materials to be used as a carrier for Bovine serum albumin (BSA) protein. This study successfully synthesized 0.07 mole of SO42-substituted HA using the reflux microwave-assisted wet precipitation method and fully characterized it using modern techniques. In particular, XRD, XPS, Raman, FESEM, and BET techniques were used to explore the micro-structure properties of materials. The results shows that the addition of SO42-ions amplified the lattice parameters and surface area of HA, and the particles shape was changed from semi-spherical to rod like shape. Adsorption and desorption of protein molecules were evaluated using BSA protein for 24 h at 37 degrees C. BSA loading capacity and release behaviours were significantly improved with the incorporation of SO42-ions. The SO4- HA materials hold a promising future for being used as a carrier for protein molecules.