MESOPOROUS SULPHATE DOPED HYDROXYAPATITE NANOPARTICLES FOR CONTROLLED RELEASE OF PROTEINS
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Univ Chemistry & Technology, Prague
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The purpose of this study is to synthesize and characterize the mesoporous nanostructure of Hydroxyapatite (HA), evaluate the impact of the addition of sulphate ions (SO42-) on the microstructure properties of HA, and assess the ability of the prepared materials to be used as a carrier for Bovine serum albumin (BSA) protein. This study successfully synthesized 0.07 mole of SO42-substituted HA using the reflux microwave-assisted wet precipitation method and fully characterized it using modern techniques. In particular, XRD, XPS, Raman, FESEM, and BET techniques were used to explore the micro-structure properties of materials. The results shows that the addition of SO42-ions amplified the lattice parameters and surface area of HA, and the particles shape was changed from semi-spherical to rod like shape. Adsorption and desorption of protein molecules were evaluated using BSA protein for 24 h at 37 degrees C. BSA loading capacity and release behaviours were significantly improved with the incorporation of SO42-ions. The SO4- HA materials hold a promising future for being used as a carrier for protein molecules.
Açıklama
Anahtar Kelimeler
Hydroxyapatite, Sulphate, Characterizations, Adsorption and desorption, Protein
Kaynak
Ceramics-Silikaty
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
66
Sayı
4
