Yazar "Uguz, Mustafa" seçeneğine göre listele

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    Cytokine filter experience in covid-19 treatment; a single center study
    (2022) Uguz, Mustafa; Atıs, Seref Emre
    Aim: Several studies state that the primary underlying mechanism of severe COVID-19 cases includes the hyperimmune response triggered following SARS-CoV-2 infections and the subsequent cytokine storm. The study aims to examine the effects of cytokine filters on patients with COVID-19 who developed cytokine storms. Material and Methods: This is a retrospective, cross-sectional study. All the patients included in the study had tested positive for COVID-19 in their real-time polymerase chain reaction test. The study included patients with COVID-19 who developed cytokine storms and were treated in the ICU. The patients were divided into two groups those who applied cytokine filter or not. The demographic data and laboratory findings of the patients were recorded. The patient outcomes were categorized as discharged or deceased. Results: The study included 149 patients. Patients’ mean age was 56±29 years, and 125 (83.9%) patients were male. A significant decrease was detected in the levels of fibrinogen, ferritin, lymphocyte count, and CRP after cytokine filtration (p
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    Factors predicting hyperimmune response in COVID-19 patients presenting to the emergency department
    (Bayrakol Medical Publisher, 2022) Atis, Seref Emre; Uguz, Mustafa
    Aim: The aim of this study is to determine the predictive parameters that can be used in the early determination of hyperimmune response syndrome in the Emergency Department. Material and Methods: This is a cross-sectional, retrospective study. Patients over the age of 18 who were admitted to the emergency department with a pre-diagnosis of COVID-19, and who were admitted to the intensive care unit were included in the study. Demographic data and laboratory findings were obtained from the hospital information system and patient files. Patients' thoracic computerized tomography images were classified into two groups. The classic involvement includes bilateral basal ground-glass opacities, crazy paving, reverse halo, per lobular pattern, and peripheral consolidation. All other images were included as non-classic COVID-19 involvement. Results: A total of 202 patients were included. Hyperimmune response development was detected in 74 (36.6%) patients. When laboratory values were examined, ferritin and ALT values were found to be higher, WBC and lymphocyte values were found to be lower in patients who developed a hyperimmune response (p<0.01, p<0.01, p=0.038 and p=0.004, respectively). In the logistic regression analysis of the values that can be effective in the development of the hyperimmune response, classic imaging had a statistically significant effect (Odds ratio 0.449 [95% confidence interval, CI = 0.244-0.827], non-classic vs classic[reference]). No statistically significant effect was found in the analysis of other values. Discussion: Classical chest tomography findings can be useful as a preliminary parameter in the development of hyperimmune response.