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Öğe Candida glabrata Pneumonia in a Patient with Chronic Obstructive Pulmonary Disease(Hindawi Ltd, 2016) Yazici, Onur; Cortuk, Mustafa; Casim, Hasan; Cetinkaya, Erdogan; Mert, Ali; Benli, Ali RamazanPneumonia remains an important cause of morbidity and mortality among infectious diseases. Streptococcus pneumoniae and viruses are the most common cause of pneumonia. Candidiasis in such patients has been associated with haemodialysis, fungal colonization, exposure to broad-spectrum antibiotics, intensive care unit (ICU) hospitalization, and immunocompromised patients. The most common cause of infection is C. albicans. The case presented here is of a 66-year-old male patient diagnosed with C. glabrata. The patient suffered from chronic obstructive pulmonary disease.Öğe Evaluation of Causes Application on Medical Board(Duzce Univ, 2016) Benli, Ali Ramazan; Yazici, Senay Demir; Yazici, Onur; Cortuk, Mustafa; Inci, Habibe; Benli, Neriman CetinAim: Disabled patients are admitted to the medical board to determine the disability rate in order to use the occupational, health and social rights in Turkey. According to the law, over 40% of individuals with disabilities, based on the severity of their disability and illness rate, have different rights. We aimed to contribute to epidemiological data on people with disabilities in our city. Methods: Between January 2014 and December 2014 the records of patients were admitted to the medical board of Karabuk University Training and Research Hospital, and they were analyzed retrospectively. Results: In the medical board in January 2014-December 2014, 2637 cases were evaluated. 1554 of these patients were male (58.9%), 1083 women (41%). With the increase of age, the frequency of application increased, too. Maximum application was in the group who are above 65 years of age. The numbers of cases by over 40% points are 1834 people (69.5%). 1055 of them were men (40%), 779 were women (29.5%). When the cases were evaluated according to the distribution of branches, 976 cases (37%) in musculoskeletal system were identified. The least disability was in Obstetrics and Gynecology with 8 cases (0.3%). Conclusion: Quality of life of the disabled population and the quality of services which are offered to them are closely related to the level of development of the society. In order to improve the life quality of disabled people, regional and country wide data of these people are needed.Öğe The Monocyte/HDL Cholesterol Ratio in Obstructive Sleep Apnea Syndrome(Galenos Yayincilik, 2019) Acat, Murat; Yazici, OnurObjective: Obstructive Sleep Apnea syndrome (OSAS) is the most common condition among sleep-related respiratory disorders. The etiology is not clear. However, systemic and local inflammation in the respiratory tract of the patients has been acknowledged. Monocytes and macrophages play the critical role in the inflammation process. These cells participate in the release of the proinflammatory cytokines in inflammation sites. High-density lipoprotein (HDL) cholesterol is a molecule with an anti-inflammatory effect. Monocyte/HDL cholesterol ratio (MHR) is an inflammation marker being used recently. In our study, we aimed to compare inflammation marker levels between patients diagnosed with OSAS with subsequent polysomnography and the non-OSAS group, determine the relationship between the severity of OSAS and MHR and, investigate the utility of the MHR for diagnosing OSAS. Materials and Methods: The data from the patients' files who had polysomnography due to OSAS symptoms in our unit between July 2017 and December 2017 have been retrospectively analyzed, and polysomnography results were recorded. Demographic data and the results of biochemistry and complete blood count panels of patients with OSAS and who were not also were recorded. Results: Out of 147 patients who underwent polysomnography in the period identified, 104 were diagnosed with OSAS. Monocyte count and MHR values were significantly high (p<0.0001 in both) and HDL levels were significantly low (p=0.03) in OSAS group. There was also a moderately significant positive correlation between apnea-hypopnea index (AHI) and MHR (p<0.0001, r=0.411). Conclusion: MHR may be a useful tool for diagnosing OSAS. Because of the positive correlation between MHR and AHI which represents the severity of the disease, MHR may be used for the classification of OSAS.Öğe Moxifloxacin related thrombocytopeniae: A case report(Turkish Assoc Tuberculosis & Thorax, 2016) Cortuk, Mustafa; Benli, Ali Ramazan; Koroglu, Mustafa; Yazici, Onur; Acat, Murat; Casim, Hasan; Cetinkaya, ErdoganDrug-induced thrombocytopenia can be caused by various medications, most frequently, antibiotics. There have been reports of thrombocytopenia cases due to the usage of quinolone antibiotics, although moxifloxacin-related thrombocytopenia has been reported very rarely. The case is here presented of a 60-year old male with chronic obstructive pulmonary disease who presented with complaints of progressively worsening dyspnea. After hospitalization, progressive thrombocytopenia was detected which had started on the 3rd day of moxifloxacin treatment. Other causes of thrombocytopenia were excluded and the thrombocyte count returned to normal after discontinuation of moxifloxacin.Öğe Retrospective review of epidemic viral pneumonia cases in Turkey: A multicenter study(Spandidos Publ Ltd, 2017) Cortuk, Mustafa; Acat, Murat; Yazici, Onur; Yasar, Zehra; Kiraz, Kemal; Ataman, Sena Yapicioglu; Tanriverdi, ElifInfluenza A (H1N1) caused its first pandemic in 2009 in USA and Mexico. Since then, clinicians have exercised great care in order to make an early diagnosis of viral pneumonias. This is due in part to pandemic influenza A infection having greater impact on populations <65 years old than other viral strains, including seasonal influenza. Chest radiographies of those affected displayed a rapid progression of patchy infiltrates, and a large proportion of individuals required admission to intensive care units (ICU). Despite efforts, patients infected with the virus had a high mortality rate. The present multicenter study aimed to retrospectively evaluate the clinical, demographic and prognostic characteristics of patients diagnosed with epidemic viral pneumonia in Turkey. A total of 92 patients were included in the study. The Student's t-test and Chi-square tests were performed to analyze quantitative data, assuming a normal distribution, and to analyze qualitative data, respectively. Stepwise logistic regression was used to evaluate the effects of demographic variables and laboratory values on the virus mortality rate. The male/female ratio was 42/50 and the mean age was 48.74 +/- 16.65 years. A total of 69 (75%) patients were unvaccinated against influenza. The most common symptoms were cough (87%) and fever (63%). Chest computed tomography showed peripheral patchy areas of the lungs of ground glass density in 38 patients (41.3%). A total of 22 (59.4%) patients had H1N1, 5 (12.5%) patients had influenza B, and 38 (41.3%) patients met the criteria for admission to the ICU. Of these patients, 20 (52.63%) were monitored with a mechanical ventilator, with a noninvasive ventilator being adequate for 10 (26.32%) of patients. The length of stay in the ICU was 6.45 +/- 5.97 days and the duration of mechanical ventilation was 5.06 +/- 4.69 days. A total of 12 (13.04%) patients in the ICU succumbed. Logistic regression analysis revealed that among the parameters possibly associated with mortality, being an active smoker increased the risk of mortality 7.08-fold compared to other groups (P=0.005). In conclusion, viral pneumonia remains a significant health problem during the winter period. Considering the high number of ICU admissions and high rate of mortality for patients in the present study, earlier initiation of antiviral therapy is necessary. Active smoking increased mortality in viral pneumonia.