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    Dynamic thiol/disulphide homeostasis in patients with Uterine Myoma
    (Elsevier, 2017) Eroglu, Semra; Haskul, Ismail; Aziz, Vusale; Yurtcu, Engin; Karatas, Fatih; Neselioglu, Salim; Erel, Ozcan
    Background: The aim of this study is to measure and compare the dynamic thiol and disulphide homeostasis between patients with Uterine Myoma (UM) and healthy subjects. Material and method: A total of 54 patients with UM who were diagnosed by transvaginal ultrasonography and 37 age-and body mass index-matched healthy individuals were included in this study. Thiol/disulphide homeostasis was measured by a novel automatic spectrophotometric method. Results: The mean serum native thiol, disulphide, and thiol levels were statistically lower in UM group than those in the control group [(284.66 +/- 59.41 mu mol/L vs. 320.98 +/- 56.17 mu mol/L, P < 0.0001), (17.27 +/- 5.59 mu mol/L vs. 22.38 +/- 6.93 mu mol/L P < 0.0001) and (319.21 +/- 61.69 vs. 365.76 +/- 61.46 mu mol/L, P < 0.0001), respectively]. There were no statistically significant differences in ratios of the disulphide/native thiol: native thiol/total thiol, and disulphide/total thiol among patients with UM versus healthy control group (P = 0.096, 0.092, 0.092, respectively). Conclusion: It was found that the native thiol, total thiol, and disulphide levels in patients with UM decreased while the ratio of native thiol/disulphide remained unchanged. It is necessary to investigate whether these findings have a role in the etiology and clinical course of the UM. (C) 2017 Elsevier B.V. All rights reserved.
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    The Effects of the Social Environment and Socio-Economic Conditions of Pregnant Relatives of Pregnant Women in Karabuk on the Way of Birth
    (Duzce Univ, 2020) Mutlu, Sibel; Yurtcu, Engin
    Objective: Our country has a young and growing population and has high birth rates. In this study, we aimed to investigate the effect of pregnant women, their relatives and social structure on cesarean delivery rates in our country. Methods: A total of 264 pregnant women who were hospitalized the years of 2017-2018 were examined. A questionnaire was applied to the pregnant women, their spouses and the mothers of the couples. In the questionnaire forms, there were questions about which type of birth they prefer, the approximate monthly income of the patients in both groups, their educational status, the suggestions and requests of the pregnant women, and the social and demographic characteristics of the pregnant women. Survey data; Pregnant and relatives were collected as a result of face-to-face interview after hospitalization. Results: In cesarean section births; In pregnancies where the pregnant and relatives prefer cesarean delivery type, resulting in vaginal delivery; pregnant and her relatives preferred normal vaginal delivery more frequently. It was determined that the normal birth rate was higher in patients with income levels below 3000 Turkish liras and education level below university level. Cesarean delivery rates were lower in pregnant women living in extended families than nuclear families. Conclusions: According to our study; pregnancy and relatives preferences about the type of birth is seen to affect the way of birth, income and education level decreases and living in a large family increases the normal birth rates.
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    Protective Effect of Allopurinol on Experimental Ovarian Ischemia-Reperfusion Injury Model of Rats
    (Sci Printers & Publ Inc, 2020) Yurtcu, Engin; Togrul, Cihan; Deveci, Engin
    OBJECTIVE: To investigate the effect of allopurinol on an experimentally induced ovarian ischemia-repel fusion model. STUDY DESIGN: Female rats in the estrous cycle (n= 32) were divided into sham, ischemia, ischemia-reperfusion, and ischemia-reperfusion + allopurinol-treated groups. In the sham group the ovaries were opened and closed. In the ischemia group the ovaries were sealed for 2-hour ischemia. In the ischemia-reperfusion group, after ischemia, 2.5 hours of reperfusion was done. In the ischemia-reperfusion + allopurinol group, 3 hours after ischemia-reperfusion, 50 mg/kg allopurinol was administered. RESULTS: In the allopurinol-administered group, MDA levels were decreased. GSH values were decreased in the ischemia and ischemia-reperfusion group but increased in the allopurinol-treated group as compared to the control group. Caspase-3 expression was positive in enlarged corpus luteum cells. sFlt-1 expression was positive in vascular endothelial cells between preantral and antral follicles and some macrophages but negative in granular cells. In the ischemia group, sFlt-1 expression was positive in degenerative preantral and antral follicle cells, endothelial cells, and intense inflammatory cells. In the ischemia-reperfusion group, increased sFlt-1 expression was observed in luteal cells of the corpus luteum, vascular endothelial, and inflammatory cells. In the ischemia-reperfusion +allopurinol group, granular cells and corpus luteum cells showed decreased sFlt-1 expression, while being positive in vascular endothelial cells. CONCLUSION: Allopurinol inhibits development of apoptosis and reduces oxidative load in the ischemia-reperfusion stage, thus protecting the ovary from damage.
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    Relationship between awareness of cervical cancer and HPV infection and attitudes towards HPV vaccine among women aged 15-49 years: a cross-sectional study
    (Associacao Paulista Medicina, 2022) Yurtcu, Engin; Dogan, Reyhan Aydin; Karaaslan, Busra; Mutlu, Sibel
    BACKGROUND: Cervical cancer is a type of cancer caused by human papillomavirus (HPV). OBJECTIVE: To determine the relationship between awareness of cervical cancer and HPV infection and attitudes towards HPV vaccine among women aged 15-49 years. DESIGN AND SETTING:Cross-sectional study conducted at Karabuk Training and Research Hospital, Turkey. METHODS: 500 women who visited the gynecology outpatient clinic of a public hospital between July 15 and December 31, 2019, were selected through random sampling. Data were collected using a sociodemographic questionnaire comprising nine questions (created by the researchers), the HPV and Cervical Cancer Awareness Questionnaire and the Carolina HPV Immunization Attitudes and Beliefs Scale. RESULTS: The relationship between the awareness questionnaire and the beliefs scale was explained through simple effect modeling of a structural equation.The women's knowledge score regarding cervical cancer and HPV infection was 4.69 +/- 4.02 out of 15. Women were afraid of being diagnosed with cervical cancer and HPV infection, but they did not have sufficient information. They had poor information about the HPV vaccine, did not know how to obtain the vaccine and did not have enough information about its benefits and harmful effects. Women who were afraid of getting cervical cancer, and who thought that they were at risk, had more information about the HPV vaccine. CONCLUSION: Women need information about cervical cancer, HPV infection and the HPV vaccine. Midwives, nurses and physicians who provide healthcare services in gynecological follow-ups should provide information to women about the HPV vaccine and cervical cancer.
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    The role of trimetazidine in ischemia/reperfusion damage treatment in an ovary torsion model experimentally induced in rats
    (Taylor & Francis Inc, 2022) Dirican, Aylin Onder; Doganay, Melike; Inal, Hasan Ali; Yurtcu, Engin; Togrul, Cihan; Bektas, Gizem; Caydere, Muzaffer
    The aim of this experimental animal study was to investigate the histopathological and biochemical efficacy of trimetazidine (TMZ) in decreasing ovary damage in an ovary ischaemia/reperfusion (I/R) model in the rat. A total of 35 Wistar albino female rats were randomly separated into five groups, n = 7 per group: Group 1: Sham (S) was only given a laparotomy procedure. Group 2: Ischaemia (I) group with 2-hour ischaemia using a vascular sutur. Group 3: Ischaemia/Reperfusion (I/R) group with 2 hour ischaemia and 2-hour reperfusion. Group 4: Sham + 10 mg/kg orally TMZ (S + TMZ). Group 5: I/R + 10 mg/kg oral TMZ (I/R + TMZ) group with 2 hours ischaemia and 2 hours reperfusion after the administration orally 10 mg/kg oral TMZ. Two daily doses of TMZ were orally administered to Group 4 (S + TMZ) and Group 5 (I/R + TMZ) for three days. TMZ significantly decreased vascular congestion, haemorrhage, and polymorphonuclear leukocyte infiltration in group 5 compared to group 3 (p < .05). Despite TMZ decreased the malondialdehyde, total oxidant status, and oxidative stress index values, these decreases were not statistically significant (p > .05). TMZ which is an antioxidant agent can efficiently prevent in I/R damage in rat ovaries but further studies are necessary in order to implement it in the clinical settings.IMPACT STATEMENT What is already known on this subject? Adnexial torsion is the most common gynecological emergency and there are no specific clinical, laboratories, or radiological findings for adnexal torsion. Unfortunatelly, the currently accepted treatment is adnexal detorsion. Cytoprotective effects of Trimetazidine (TMZ), an antianginal drug, are well-defined and it has been demonstrated to improve oxidative stress markers and limits membrane damage induced by reactive oxygen species and protects tissues from free radicals with its antioxidant effects. The aim of this study is to investigate the effects of TMZ in experimentally induced adnexal torsion in rats and to investigate possible effects in maintaining ovarian reserve to prevent I/R damage or reperfusion damage. What do the results of this study add? Our study showed that TMZ significantly decreased vascular congestion, haemorrhage, and PMNL infiltration. TMZ decreased the malondialdehyde, total oxidant status, and the oxidative stress index values, but these decreases were not statistically significant. What are the implications of these findings for clinical practice and/or further research? Although various antioxidant drugs and chemicals have been used to protect the ovaries against I/R damage, they have not been demostrated to prevent it completely. TMZ, an antioxidant efficacy agent, has been shown to prevent ovarian I/R damage by suppressing inflammation in terms of histopathological parameters. Further studies involving a greater number of experimental animals are required before using TMZ for the treatment of humans with I/R damage in the clinical setting.