Dynamic thiol/disulphide homeostasis in patients with Uterine Myoma
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: The aim of this study is to measure and compare the dynamic thiol and disulphide homeostasis between patients with Uterine Myoma (UM) and healthy subjects. Material and method: A total of 54 patients with UM who were diagnosed by transvaginal ultrasonography and 37 age-and body mass index-matched healthy individuals were included in this study. Thiol/disulphide homeostasis was measured by a novel automatic spectrophotometric method. Results: The mean serum native thiol, disulphide, and thiol levels were statistically lower in UM group than those in the control group [(284.66 +/- 59.41 mu mol/L vs. 320.98 +/- 56.17 mu mol/L, P < 0.0001), (17.27 +/- 5.59 mu mol/L vs. 22.38 +/- 6.93 mu mol/L P < 0.0001) and (319.21 +/- 61.69 vs. 365.76 +/- 61.46 mu mol/L, P < 0.0001), respectively]. There were no statistically significant differences in ratios of the disulphide/native thiol: native thiol/total thiol, and disulphide/total thiol among patients with UM versus healthy control group (P = 0.096, 0.092, 0.092, respectively). Conclusion: It was found that the native thiol, total thiol, and disulphide levels in patients with UM decreased while the ratio of native thiol/disulphide remained unchanged. It is necessary to investigate whether these findings have a role in the etiology and clinical course of the UM. (C) 2017 Elsevier B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
Serum, Thiol, Disulphide, Ratio, Uterine myoma
Kaynak
European Journal of Obstetrics & Gynecology and Reproductive Biology
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
216
