Highly Promising Antitumor Agent of a Novel Platinum(II) Complex Bearing a Tetradentate Chelating Ligand

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dc.authoridUlukaya, Engin/0000-0003-4875-5472
dc.authoridAKAR, Okan/0000-0001-8687-2034
dc.authoridSengul, Abdurrahman/0000-0001-6851-4612
dc.authoridYILMAZ, ISMAIL/0000-0002-0139-0122
dc.authoridErkisa Genel, Merve/0000-0002-3127-742X
dc.contributor.authorYilmaz, Ismail
dc.contributor.authorAkar, Okan Remzi
dc.contributor.authorErkisa, Merve
dc.contributor.authorSelvi, Selin
dc.contributor.authorSengul, Abdurrahman
dc.contributor.authorUlukaya, Engin
dc.date.accessioned2024-09-29T16:00:59Z
dc.date.available2024-09-29T16:00:59Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractA new mononuclear cationic platinum(II) coordination compound with 6,6'-bis(NH-benzimidazol-2-yl)-2,2'-bipyridine (L) ligand having N-4-tetradentate binding pocket [Pt(L)]-Cl-2.2H(2)O (Complex 1) was synthesized and characterized by FTIR(ATR), UV-vis, H-1 NMR, APCI and MALDI MS, and CHN analysis. The antigrowth effect of Complex 1 was tested in breast cancer (MDA-MB-231), lung cancer (A549), colorectal cancer (HCT-116), prostate cancer (PC-3) cell lines, and bronchial epithelial cell line (BEAS-2B) by the SRB and ATP cell viability assays. Apoptosis was detected with Annexin V, mitopotential, BCL-2 inactivation, and gamma H2AX assays by flow cytometry. Complex 1 was found to have cytotoxic activity of MDA-MB-231, A549, HCT-116, and PC-3 cancer cell lines in a dose-dependent manner for 48 h. Complex 1 has been found to cause cell death through different mechanisms depending on the type of cancer. The findings indicated that complex induced intrinsic apoptosis with the increased mitochondrial membrane depolarization level, Bcl-2 inactivation, and DNA damage in PC-3 and A549 cell lines.en_US
dc.description.sponsorshipTurkish Scientific and Technical Research Council (TUBITAK) [TBAG-2450(104T060)]en_US
dc.description.sponsorshipThis work was partly supported by the Turkish Scientific and Technical Research Council (TUBITAK) [grant number TBAG-2450(104T060)].en_US
dc.identifier.doi10.1021/acsmedchemlett.9b00676
dc.identifier.endpage948en_US
dc.identifier.issn1948-5875
dc.identifier.issue5en_US
dc.identifier.pmid32435409en_US
dc.identifier.scopus2-s2.0-85082528330en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage940en_US
dc.identifier.urihttps://doi.org/10.1021/acsmedchemlett.9b00676
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5478
dc.identifier.volume11en_US
dc.identifier.wosWOS:000535281200051en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofAcs Medicinal Chemistry Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPlatinumen_US
dc.subjectN-4-donor liganden_US
dc.subjectbenzimidazoleen_US
dc.subjectpyridineen_US
dc.subjectcytotoxicityen_US
dc.subjectapoptosisen_US
dc.titleHighly Promising Antitumor Agent of a Novel Platinum(II) Complex Bearing a Tetradentate Chelating Liganden_US
dc.typeArticleen_US

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