Are platelet and eosinophil parameters indicators of predicting the development of erectile dysfunction after radical prostatectomy?
Küçük Resim Yok
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
INTRODUCTION: Erectile dysfunction(ED) may develop in 14-90% following radical prostatectomy(RP).Development of ED is due to neurovascular damage during surgery. In our study, we aimed to evaluate whetherthe platelet and eosinophil parameters are prognostic factors in predicting ED after prostatectomy.METHODS: Data of 181 patients who underwent RP between January 2010 and December 2016 were analyzedretrospectively. In the preoperative period, platelet count, mean platelet volume (MPV), platelet distributionwidth (PDW) and eosinophil count were recorded. The patients were evaluated for ED according to theInternational Erectile Function Index in preoperatively and postoperatively. In the postoperative 12th month, EDwas observed in 128 patients following RP. Among them, 82 patients with postoperative ED were included inGroup I, and 46 patients without postoperative ED were included in Group II.RESULTS: Age (p=0.281) and body mass index (p=0.851) had no significant difference between groups. Inpreoperative period, mean platelet count (292.18±51.62 vs. 240.15±46.25, p<0.001), mean MPV value(8.77±1.24 vs. 6.17±0.87, p<0.001) and mean eosinophil count (0.57±0.16 vs. 0.47±0.10, p<0.001) were higher in Group I. Mean PDW value (16.21±1.84 vs.16.75±1.77, p=0.110) had no significantly difference. According toROC analysis, the cut-off values for platelet, MPV and eosinophil were 242 (AUC: 0.783, p<0.001), 7.24 (AUC:0.951, p<0.001) and 0.5 (AUC: 0.675, p=0.001), respectively. In multivariate analysis, MPV and eosinophilwere found to be more important independent factors in predicting ED after RP.DISCUSSION and CONCLUSION: It is shown that platelet, MPV and eosinophil are independent predictivefactors in predicting ED following prostatectomy.
Açıklama
Anahtar Kelimeler
Tıbbi İnformatik, Genel ve Dahili Tıp, Temel Sağlık Hizmetleri, Onkoloji, Sağlık Bilimleri ve Hizmetleri
Kaynak
ACTA ONCOLOGICA TURCICA
WoS Q Değeri
Scopus Q Değeri
Cilt
52
Sayı
1
