Blood and Stool Arsenic Levels Are Decisive for Diagnosing Children's Functional Gastrointestinal Disease (FGD)

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dc.authoridCENGIZ, Mustafa/0000-0002-6925-8371
dc.contributor.authorBilici, Namik
dc.contributor.authorDogan, Erkan
dc.contributor.authorSevinc, Eylem
dc.contributor.authorSevinc, Nergiz
dc.contributor.authorAkinci, Gulsema
dc.contributor.authorMusmul, Ahmet
dc.contributor.authorCengiz, Mustafa
dc.date.accessioned2024-09-29T15:54:34Z
dc.date.available2024-09-29T15:54:34Z
dc.date.issued2022
dc.departmentKarabük Üniversitesien_US
dc.description.abstractPediatric gastroenteritis is a potentially fatal disease that accounts for 10% of childhood deaths. The main risk is environmental factors and nutrition. Arsenic (As) is commonly found in the earth's crust. As is an essential element that can form many organic compounds. In children, it causes diarrhea, gums, tongue lesions, diabetes, conjunctivitis, ocular opacity, and impaired immune response. It also causes low growth, mental retardation, and neurological problems. It is also known as the cause of many cancers that originate at an early age. Regionally, there is an iron and steel industry for almost a century. According to the Rome IV criteria, the blood and stools of 50 children aged 6-18 years, male and female, living in our province with functional gastrointestinal disease (FGD), were screened for As, and compared with the Healthy group (control) of 30 children. The results were evaluated with the Mann-Whitney Rank Sum Test. When blood and stool As values in males were compared with control samples, a high level of significance (p = 0.001) was found between both blood and stool As values in sick males and the control group (p < 0.005). In females, blood and stool As median values were also highly significant when compared with the control group (p = 0.001). According to these data, when the sick children (children with male and female gender) are compared with the healthy ones, the difference is highly significant (p < 0.005). High blood As levels in children indicate environmental pollution. It can be said that blood As levels are high as a result of food, water, and inhaler exposure. The presence of a high level of significant difference in stool means that the amount of As is high in the foods consumed daily. High levels of As are in blood and stools; It was evaluated that FGD could be the cause of nausea, diarrhea, vomiting, and colic. The increase in blood and stool As values due to environmental pollution is an important reason for FGD. For diseases of uncertain cause (such as FGD) resulting from chronic As exposure, blood and especially stool As values are more significant than urinary As levels. In conclusion, As a diagnostic criterion, it was concluded that blood and stool As values are an important marker in children with functional abdominal pain with other metals.en_US
dc.description.sponsorshipKarabuk University Scientific Research Projects Uniten_US
dc.description.sponsorshipWe would like to thank Karabuk University Scientific Research Projects Unit for their support for our study.en_US
dc.identifier.doi10.1007/s12011-021-02919-4
dc.identifier.endpage3059en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue7en_US
dc.identifier.pmid34564832en_US
dc.identifier.scopus2-s2.0-85115706250en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3050en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-021-02919-4
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4147
dc.identifier.volume200en_US
dc.identifier.wosWOS:000700763200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArsenicen_US
dc.subjectChilden_US
dc.subjectAs exposureen_US
dc.subjectFunctional gastrointestinal disease (FGD)en_US
dc.subjectBlood and stool arsenic levelen_US
dc.titleBlood and Stool Arsenic Levels Are Decisive for Diagnosing Children's Functional Gastrointestinal Disease (FGD)en_US
dc.typeArticleen_US

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