Saffron (its active constituent, crocin) supplementation attenuates lipid peroxidation and protects against tissue injury

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dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.contributor.authorAltinoz, E.
dc.contributor.authorOzmen, T.
dc.contributor.authorOner, Z.
dc.contributor.authorElbe, H.
dc.contributor.authorErdemli, M. E.
dc.contributor.authorBag, H. G.
dc.date.accessioned2024-09-29T16:08:28Z
dc.date.available2024-09-29T16:08:28Z
dc.date.issued2016
dc.departmentKarabük Üniversitesien_US
dc.description.abstractThe aim of the current study was to investigate the outcomes in a rat model of an acute swimming exercise induced oxidative stress in brain, kidney, liver, skeletal and cardiac muscles using supplementation with crocin. Rats were divided into the eight groups; Normal Control (NC: Untreated and did not swim), Crocin Control (CC: Received crocin and did not swim), Exercise-1 (E-1: Untreated and swam), Exercise-24 (E-24: Untreated and swam), Exercise-48 (E-48: Untreated and swam), Exercise+Crocin-1 (EC-1: Received crocin and swam), Exercise+Crocin-24 (EC-24: Received crocin and swam), Exercise+Crocin-48 (EC-48: Received crocin and swam). The malondialdehyde (MDA) and xanthine oxidase (XO) enzymes levels increased after swimming in untreated and crocin treated groups, but there was a lower increase in crocin treated groups. The highest MDA levels in all tissues were observed in E-1 compared to all other groups. There were significant differences between control and exercise groups in MDA levels of tissues (p < 0.001). In contrast, there were significant differences between control and exercise groups in glutathione (GSH) levels of tissues. In addition, the crocin supplementation significantly increased GSH levels and decreased MDA and XO enzyme levels when compared to untreated exercise groups. Crocin can protect the tissues against exercise induced oxidative stress by enhancing antioxidant activity (Tab. 3, Fig. 1, Ref. 37). Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2016_075
dc.identifier.endpage387en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue7en_US
dc.identifier.pmid27546539en_US
dc.identifier.scopus2-s2.0-85015085312en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage381en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2016_075
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7572
dc.identifier.volume117en_US
dc.identifier.wosWOS:000384764100004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcrocinen_US
dc.subjectGSHen_US
dc.subjectMDAen_US
dc.subjectoxidative stressen_US
dc.subjectratsen_US
dc.subjectexerciseen_US
dc.titleSaffron (its active constituent, crocin) supplementation attenuates lipid peroxidation and protects against tissue injuryen_US
dc.typeArticleen_US

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