Factors affecting survival in patients with isolated liver-metastatic colorectal cancer treated with local ablative or surgical treatments for liver metastasis

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dc.contributor.authorSakin, A.
dc.contributor.authorSahin, S.
dc.contributor.authorAtci, M.M.
dc.contributor.authorYasar, N.
dc.contributor.authorGeredeli, C.
dc.contributor.authorAribal, S.
dc.contributor.authorAlemdar, A.
dc.date.accessioned2024-09-29T16:22:33Z
dc.date.available2024-09-29T16:22:33Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractPurpose: Local treatments for isolated synchronous or metachronous liver metastases in colorectal cancer (CRC) have been shown to improve overall survival (OS). The aim of this study was to investigate the factors affecting OS in CRC patients with isolated liver metastasis in whom the primary tumor and corresponding liver metastasis were treated with curative intent using local ablative or surgical methods. Methods: A total of 47 CRC patients presenting with an initial or subsequent isolated liver metastasis, who were treated with local surgical or ablative treatment for liver metastasis with curative intent, were enrolled in this study between 2007 and 2017. The possible factors affecting OS were analyzed. Results: Out of the 47 patients, 35 (74.5%) were male. The median age was 61 (25-80) years. Thirty-four (72.3%) patients underwent liver metastasectomy, while 13 (27.7%) patients were treated with non-surgical local ablative therapies (NSLAT) for liver metastasis. Median OS (mOS) could not be reached in patients who underwent metastasectomy at the time of diagnosis compared to 55 months in those undergoing metastasectomy following a chemotherapy period (p=0.03). Patients treated with NSLAT had a mOS of 60 months compared to “not reached’’ in those who underwent liver metastasectomy (p=0.45). mOS was higher in patients with pT4 stage vs. <pT4 stages (28 months vs. not reached, p=0.02, respectively). Multivariate regression analysis revealed that undergoing liver metastasectomy at the time of diagnosis (HR 0.10; 95%Cl: 0.01-0.82) and pT4 stage (HR 4.365; 95%Cl: 1.27 - 14.98) were the most important independent factors affecting OS. Conclusion: This study demonstrated that CRC patients with isolated liver metastasis, <pT4 stage and curative liver metastasectomy achieved the best survival outcomes. © 2019 Zerbinis Publications. All rights reserved.en_US
dc.identifier.endpage1808en_US
dc.identifier.issn1107-0625
dc.identifier.issue5en_US
dc.identifier.pmid31786840en_US
dc.identifier.scopus2-s2.0-85075255444en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1801en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14619/10143
dc.identifier.volume24en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherZerbinis Publicationsen_US
dc.relation.ispartofJournal of B.U.ON.en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColorectal canceren_US
dc.subjectLiver metastasisen_US
dc.subjectLocal ablative treatmentsen_US
dc.subjectMetastasectomyen_US
dc.subjectSurvivalen_US
dc.titleFactors affecting survival in patients with isolated liver-metastatic colorectal cancer treated with local ablative or surgical treatments for liver metastasisen_US
dc.typeArticleen_US

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