Polygenic prediction of the phenome, across ancestry, in emerging adulthood

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dc.authoridMoore, Ashlee/0000-0002-6577-3050
dc.contributor.authorDocherty, Anna R.
dc.contributor.authorMoscati, Arden
dc.contributor.authorDick, Danielle
dc.contributor.authorSavage, Jeanne E.
dc.contributor.authorSalvatore, Jessica E.
dc.contributor.authorCooke, Megan
dc.contributor.authorAliev, Fazil
dc.date.accessioned2024-09-29T16:00:58Z
dc.date.available2024-09-29T16:00:58Z
dc.date.issued2018
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackgroundIdentifying genetic relationships between complex traits in emerging adulthood can provide useful etiological insights into risk for psychopathology. College-age individuals are under-represented in genomic analyses thus far, and the majority of work has focused on the clinical disorder or cognitive abilities rather than normal-range behavioral outcomes.MethodsThis study examined a sample of emerging adults 18-22 years of age (N = 5947) to construct an atlas of polygenic risk for 33 traits predicting relevant phenotypic outcomes. Twenty-eight hypotheses were tested based on the previous literature on samples of European ancestry, and the availability of rich assessment data allowed for polygenic predictions across 55 psychological and medical phenotypes.ResultsPolygenic risk for schizophrenia (SZ) in emerging adults predicted anxiety, depression, nicotine use, trauma, and family history of psychological disorders. Polygenic risk for neuroticism predicted anxiety, depression, phobia, panic, neuroticism, and was correlated with polygenic risk for cardiovascular disease.ConclusionsThese results demonstrate the extensive impact of genetic risk for SZ, neuroticism, and major depression on a range of health outcomes in early adulthood. Minimal cross-ancestry replication of these phenomic patterns of polygenic influence underscores the need for more genome-wide association studies of non-European populations.en_US
dc.description.sponsorshipNational Institute on Alcohol Abuse and Alcoholism [R37AA011408, P20AA107828, K02AA018755, P50AA022537]; Virginia Commonwealth University; National Center for Research Resources [UL1RR031990]; National Institutes of Health Roadmap for Medical Research; National Institute of Mental Health [K01MH109765]; Brain & Behavior Research Foundation; National Institutes of Health National Center for Advancing Translational Science [UL1TR000058]; [T32MH20030]; [F32AA22269]; [K01AA024152]; [K01AA021399]en_US
dc.description.sponsorshipAll authors declare no conflict of interest with respect to the authorship or publication of this article. Data collection for the study was funded by R37AA011408, P20AA107828, K02AA018755, and P50AA022537 from the National Institute on Alcohol Abuse and Alcoholism, by Virginia Commonwealth University, and by UL1RR031990 from the National Center for Research Resources and National Institutes of Health Roadmap for Medical Research. A. Docherty was funded by K01MH109765 from the National Institute of Mental Health, and by a Brain & Behavior Research Foundation (formerly NARSAD) Young Investigator Award. A. Moscati, A. Moore were supported by institutional training grant T32MH20030. J. Salvatore was supported by F32AA22269 and K01AA024152. M. Cooke received support from UL1TR000058 from the National Institutes of Health National Center for Advancing Translational Science. A. Edwards was supported by K01AA021399.en_US
dc.identifier.doi10.1017/S0033291717003312
dc.identifier.endpage1823en_US
dc.identifier.issn0033-2917
dc.identifier.issn1469-8978
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-85050662403en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1814en_US
dc.identifier.urihttps://doi.org/10.1017/S0033291717003312
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5455
dc.identifier.volume48en_US
dc.identifier.wosWOS:000440180100007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofPsychological Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCardiovascularen_US
dc.subjectgeneticen_US
dc.subjectneuroticismen_US
dc.subjectphenomeen_US
dc.subjectpolygenicen_US
dc.subjectschizophreniaen_US
dc.titlePolygenic prediction of the phenome, across ancestry, in emerging adulthooden_US
dc.typeArticleen_US

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