Fibulins: a new biomarker for pulmonary thromboembolism?

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dc.authoridAkbay, Ertan/0000-0002-9146-0621
dc.authoridAcat, Murat/0000-0002-7163-4882
dc.authoridHaskul, Ismail/0000-0001-5125-1035
dc.authoridUGUR CHOUSEIN, EFSUN GONCA/0000-0002-8029-6627
dc.contributor.authorAcat, Murat
dc.contributor.authorDikis, Ozlem Sengoren
dc.contributor.authorDulger, Seyhan Us
dc.contributor.authorAkbay, Ertan
dc.contributor.authorKarakaya, Ekrem
dc.contributor.authorHaskul, Ismail
dc.contributor.authorChousein, Efsun Gonca
dc.date.accessioned2024-09-29T16:02:52Z
dc.date.available2024-09-29T16:02:52Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjectives Fibulin-1, -2, -4, and -5 have important role in several vascular diseases. We aimed to investigate if fibulin-4 and -5 can be used as a biomarker for pulmonary thromboembolism (PTE). Methods This is a prospective case control study. Thirthy patients diagnosed with PTE and 31 in the control group. Data on demographic characteristics, length of hospital stay, blood cell counts, troponin and BNP levels, arterial blood gases, radiological reports, indication for thromboembolitic treatment, intensive care unit (ICU) requirement, and loss of life were recorded for the patients group. Serum Fibulin-4 and Fibulin-5 levels were measured. Results Fibulin 4 levels correlated positively with female gender (p < .01, r = 0.433). Positive results were found in 14 (46.7%) patients for PESI.0.1; in 7 (23.3%) patients for D-dimer; in 7 (23.3%) patients for troponin-I; in 7(23.3%) patients for BNP. Median values for Fibulin 4 level were significantly higher in patients positive for BNP. Fibulin-5 level was found to be correlated with the presence of embolism (p = .041, r = 0.263). Conclusions Fibulin-4 and -5 have been shown to be relevant to cardiovascular biology and diseases. Experimental studies and observations in humans show that they may play a role in several cardiovascular diseases particularly pulmonary embolism.en_US
dc.identifier.doi10.1080/13685538.2018.1542674
dc.identifier.endpage563en_US
dc.identifier.issn1368-5538
dc.identifier.issn1473-0790
dc.identifier.issue5en_US
dc.identifier.pmid30632874en_US
dc.identifier.scopus2-s2.0-85060096034en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage556en_US
dc.identifier.urihttps://doi.org/10.1080/13685538.2018.1542674
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5763
dc.identifier.volume23en_US
dc.identifier.wosWOS:000641856000034en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofAging Maleen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFibulinen_US
dc.subjectbiomarkeren_US
dc.subjectpulmonary embolismen_US
dc.titleFibulins: a new biomarker for pulmonary thromboembolism?en_US
dc.typeArticleen_US

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