Cytotoxicity and biocompatibility of root canal sealers: A review on recent studies

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dc.authoridKopac, Turkan/0000-0002-1642-7987
dc.authoridOzdemir, Olcay/0000-0001-8867-1551
dc.contributor.authorOzdemir, Olcay
dc.contributor.authorKopac, Turkan
dc.date.accessioned2024-09-29T16:05:06Z
dc.date.available2024-09-29T16:05:06Z
dc.date.issued2022
dc.departmentKarabük Üniversitesien_US
dc.description.abstractMany types of endodontic root canal sealers have been employed for the purpose of filling voids and irregularities in root canals, as well as reducing/removing bacterial remnants/remains. Sealers are available in various formulations, and research work to find the most appropriate ones is still ongoing. Recently, many kinds of novel root canal sealers have been introduced under various commercial names. However, most sealers are known to exhibit different levels of cytotoxicity on tissues which would result in prolonged wound healing, inflammation, and bone resorption. Preferably, sealers need to have tolerable biological and physico-chemical properties along with biocompatibility. Additives promoting the biocompatibility and bioactivity of sealers are of major concern in clinical applications. The aim of this review was to compare, evaluate, and analyze comparatively the cytotoxic effects, biocompatibility, and antimicrobial properties of recently used root canal sealers. A comprehensive literature search was made to identify their properties involving biocompatibility and cytotoxicity. In general, the sealers reported in recent literature exhibited favorable biological features in comparison to conventional ones. They promoted better cell viability and biocompatibility. The incorporation of additives influences favorably the potential negative effects. However, it has been highlighted that there is a lack of well-designed long-term clinical applications, and more in vitro and in vivo research work would be helpful to confirm the sustainability of the sealers for further clinical practice.en_US
dc.identifier.doi10.1177/22808000221076325
dc.identifier.issn2280-8000
dc.identifier.pmid35164598en_US
dc.identifier.scopus2-s2.0-85124620894en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1177/22808000221076325
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6514
dc.identifier.volume20en_US
dc.identifier.wosWOS:000760426700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal of Applied Biomaterials & Functional Materialsen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCytotoxicityen_US
dc.subjectbiocompatibilityen_US
dc.subjectbiomaterialsen_US
dc.subjectendodontic root canal sealersen_US
dc.subjectphysico-chemical propertiesen_US
dc.titleCytotoxicity and biocompatibility of root canal sealers: A review on recent studiesen_US
dc.typeReviewen_US

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