Genome-Wide Association of Heroin Dependence in Han Chinese

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dc.authoridAsherson, Philip/0000-0003-2667-2254
dc.authoridLi, Tao/0000-0003-3831-901X
dc.authoridMa, Xiaohong/0000-0003-2627-9946
dc.authoridColeman, Jonathan/0000-0002-6759-0944
dc.authoridBreen, Gerome/0000-0003-2053-1792
dc.authoridKalsi, Gursharan/0000-0002-5156-7176
dc.authoridCollier, David/0000-0003-4087-1559
dc.contributor.authorKalsi, Gursharan
dc.contributor.authorEuesden, Jack
dc.contributor.authorColeman, Jonathan R. I.
dc.contributor.authorDucci, Francesca
dc.contributor.authorAliev, Fazil
dc.contributor.authorNewhouse, Stephen J.
dc.contributor.authorLiu, Xiehe
dc.date.accessioned2024-09-29T16:06:08Z
dc.date.available2024-09-29T16:06:08Z
dc.date.issued2016
dc.departmentKarabük Üniversitesien_US
dc.description.abstractDrug addiction is a costly and recurring healthcare problem, necessitating a need to understand risk factors and mechanisms of addiction, and to identify new biomarkers. To date, genome-wide association studies (GWAS) for heroin addiction have been limited; moreover they have been restricted to examining samples of European and African-American origin due to difficulty of recruiting samples from other populations. This is the first study to test a Han Chinese population; we performed a GWAS on a homogeneous sample of 370 Han Chinese subjects diagnosed with heroin dependence using the DSM-IV criteria and 134 ethnically matched controls. Analysis using the diagnostic criteria of heroin dependence yielded suggestive evidence for association between variants in the genes CCDC42 (coiled coil domain 42; p = 2.8x10(-7)) and BRSK2 (BR serine/threonine 2; p = 4.110(-6)). In addition, we found evidence for risk variants within the ARHGEF10 (Rho guanine nucleotide exchange factor 10) gene on chromosome 8 and variants in a region on chromosome 20q13, which is gene-poor but has a concentration of mRNAs and predicted miRNAs. Gene-based association analysis identified genome-wide significant association between variants in CCDC42 and heroin addiction. Additionally, when we investigated shared risk variants between heroin addiction and risk of other addiction-related and psychiatric phenotypes using polygenic risk scores, we found a suggestive relationship with variants predicting tobacco addiction, and a significant relationship with variants predicting schizophrenia. Our genome wide association study of heroin dependence provides data in a novel sample, with functionally plausible results and evidence of genetic data of value to the field.en_US
dc.description.sponsorshipEuropean Union [302040]; Lilly UK; MRC [MC_UU_12013/5] Funding Source: UKRIen_US
dc.description.sponsorshipThis research was supported by the People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013) under the REA grant agreement no 302040. Lilly UK, provided support in the form of salaries for authors DAC and GB, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the 'author contributions' section. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.identifier.doi10.1371/journal.pone.0167388
dc.identifier.issn1932-6203
dc.identifier.issue12en_US
dc.identifier.pmid27936112en_US
dc.identifier.scopus2-s2.0-85006027661en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0167388
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6634
dc.identifier.volume11en_US
dc.identifier.wosWOS:000389587100090en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPublic Library Scienceen_US
dc.relation.ispartofPlos Oneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOpioid Receptor Geneen_US
dc.subjectRho-Gtpasesen_US
dc.subjectStructural Plasticityen_US
dc.subjectDendritic Spinesen_US
dc.subjectAbuseen_US
dc.subjectPolymorphismsen_US
dc.subjectAddictionen_US
dc.subjectRisken_US
dc.subjectVariantsen_US
dc.subjectCocaineen_US
dc.titleGenome-Wide Association of Heroin Dependence in Han Chineseen_US
dc.typeArticleen_US

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