Synthesis, characterization and cyclization reactions of some new bisthiosemicarbazones
Küçük Resim Yok
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Arkat Usa Inc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The reaction of trans-1,4-dichloro-2-butene 1 with selected phenols affords (E)-1,4-bis(aryloxy)-2-butenes 2a-d which are converted into bis-thiosemicarbazones 3a-h via the reactions with thiosemicarbazide and 4-methyl thiosemicarbazide, respectively. Similarly, 4-methyl-5-ethoxycarbonyl-2,3-dihydro-1,3-thiazoles 4a-h are synthesized via the reaction of bisthiosemicarbazones 3a-h with ethyl 2-chloroacetoacetate. trans-1,4-Dithiocyanato-2-butene 5 is obtained from the reaction of KSCN and trans-1,4-dichloro-2-butene 1. Furthermore, the bis-2-amino-1,3,4-thiadiazoles 6k and l are obtained from the reaction of trans-1,4-dithiocyanato-2-butene 5 with thiosemicarbazide and 4- methyl thiosemicarbazide, respectively. These compounds are characterized by elemental analyses, infrared, H-1-, C-13-NMR and mass spectrometry. Finally, the microbial features of all compounds are determined. Some of them exhibited microbial activities at low level, and the electronic absorption spectra of the compounds 3b, d, f and h are measured in organic solvents (MeOH, DMF, DMSO and 1,4-dioxane) with various polarities.
Açıklama
Anahtar Kelimeler
Thiosemicarbazone, di-4-methyl-5-ethoxycarbonyl-2,3-dihydro-1,3-thiazole, 2-amino-1,3,4-thiadiazole, Hantzsch reaction
Kaynak
Arkivoc
WoS Q Değeri
Q3
