Synthesis, characterization and cyclization reactions of some new bisthiosemicarbazones

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dc.authoridAlpay Karaoglu, Sengul/0000-0003-1047-8350
dc.authoridDegirmencioglu, Ismail/0000-0002-7964-0427
dc.contributor.authorEr, Mustafa
dc.contributor.authorUnver, Yasemin
dc.contributor.authorSancak, Kemal
dc.contributor.authorDegirmencioglu, Ismail
dc.contributor.authorKaraoglu, Senguel A.
dc.date.accessioned2024-09-29T16:08:26Z
dc.date.available2024-09-29T16:08:26Z
dc.date.issued2009
dc.departmentKarabük Üniversitesien_US
dc.description.abstractThe reaction of trans-1,4-dichloro-2-butene 1 with selected phenols affords (E)-1,4-bis(aryloxy)-2-butenes 2a-d which are converted into bis-thiosemicarbazones 3a-h via the reactions with thiosemicarbazide and 4-methyl thiosemicarbazide, respectively. Similarly, 4-methyl-5-ethoxycarbonyl-2,3-dihydro-1,3-thiazoles 4a-h are synthesized via the reaction of bisthiosemicarbazones 3a-h with ethyl 2-chloroacetoacetate. trans-1,4-Dithiocyanato-2-butene 5 is obtained from the reaction of KSCN and trans-1,4-dichloro-2-butene 1. Furthermore, the bis-2-amino-1,3,4-thiadiazoles 6k and l are obtained from the reaction of trans-1,4-dithiocyanato-2-butene 5 with thiosemicarbazide and 4- methyl thiosemicarbazide, respectively. These compounds are characterized by elemental analyses, infrared, H-1-, C-13-NMR and mass spectrometry. Finally, the microbial features of all compounds are determined. Some of them exhibited microbial activities at low level, and the electronic absorption spectra of the compounds 3b, d, f and h are measured in organic solvents (MeOH, DMF, DMSO and 1,4-dioxane) with various polarities.en_US
dc.description.sponsorshipResearch Fund of Karadeniz Technical University [2006.111.002.5, 2007.111.002.11]en_US
dc.description.sponsorshipThis work was supported by the Research Fund of Karadeniz Technical University. ( Project: 2006.111.002.5 and 2007.111.002.11)en_US
dc.identifier.doi10.3998/ark.5550190.0010.216
dc.identifier.endpage167en_US
dc.identifier.issn1551-7004
dc.identifier.issn1551-7012
dc.identifier.startpage149en_US
dc.identifier.urihttps://doi.org/10.3998/ark.5550190.0010.216
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7527
dc.identifier.wosWOS:000266693600016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherArkat Usa Incen_US
dc.relation.ispartofArkivocen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThiosemicarbazoneen_US
dc.subjectdi-4-methyl-5-ethoxycarbonyl-2,3-dihydro-1,3-thiazoleen_US
dc.subject2-amino-1,3,4-thiadiazoleen_US
dc.subjectHantzsch reactionen_US
dc.titleSynthesis, characterization and cyclization reactions of some new bisthiosemicarbazonesen_US
dc.typeArticleen_US

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