Cytotoxic effect of extract from Dunaliella salina against SH-SY5Y neuroblastoma cells

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dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authoridAtasever Arslan, Belkis/0000-0001-5827-8484
dc.authoridbekaroglu, maide gokce/0000-0001-9375-9910
dc.contributor.authorAtaseyer-Arslan, Belkis
dc.contributor.authorYilancioglu, Kaan
dc.contributor.authorBekaroglu, Maide G.
dc.contributor.authorTaskin, Emre
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorCetiner, Selim
dc.date.accessioned2024-09-29T16:08:29Z
dc.date.available2024-09-29T16:08:29Z
dc.date.issued2015
dc.departmentKarabük Üniversitesien_US
dc.description.abstractCytotoxic effects of essential oils extracted from Dunaliella sauna on SH-SY5Y human neuroblastoma cells were investigated in this study. GC-MS analysis was used for determination of the composition of essential oils found in Dunaliella salina extract. All experimented concentrations of Dunaliella salina extract on SH-SY5Y human neuroblastoma cells were significantly more cytotoxic than the tested concentrations of the extract on ECV304 human endothelial cells used as a control. Fifthy compounds were detected in GC-MS analysis of the extract, and five major compounds were predominantly found as follows: octadecanoic acid, methyl ester (27.43%); hexadecanoic acid, methyl ester (Cas) methyl palmitate (24.82%); 9,12,15-octadecatrienoic acid, ethyl ester, (Z,Z,Z)- (7.39%); octadecanoic acid (5.03%), pentadecanoic acid (3.60%). The cytotoxic activity of Dunaliella salina extract on SH-SY5Y human neuroblastoma cells might be due to high concentrations of octadecanoic acid and hexadecanoic acid. Furthermore, results indicate that the extract demonstrates some proliferative effect on ECV304 cells in a dose-dependent manner between 0.25 and 5 mu g/ml. These results suggest that Dunaliella sauna may have anticancer potential against human neuroblastoma cells.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [3501, 113S251]en_US
dc.description.sponsorshipWe thank Assist. Prof. Dr. Kenan Ates from Istanbul University for SH-SY5Y human neuroblastoma cells. This study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) 3501 (Project No: 113S251).en_US
dc.identifier.doi10.4149/gpb_2014034
dc.identifier.endpage207en_US
dc.identifier.issn0231-5882
dc.identifier.issn1338-4325
dc.identifier.issue2en_US
dc.identifier.pmid25675388en_US
dc.identifier.startpage201en_US
dc.identifier.urihttps://doi.org/10.4149/gpb_2014034
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7576
dc.identifier.volume34en_US
dc.identifier.wosWOS:000353181500010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeneral Physiol And Biophysicsen_US
dc.relation.ispartofGeneral Physiology and Biophysicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlgaeen_US
dc.subjectCytotoxicityen_US
dc.subjectDunaliella salinaen_US
dc.subjectEssential oilen_US
dc.subjectSH-SY5Y human neuroblastoma cellsen_US
dc.titleCytotoxic effect of extract from Dunaliella salina against SH-SY5Y neuroblastoma cellsen_US
dc.typeArticleen_US

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