Structural and Biological Analysis of Mesoporous Lanthanum Doped ?TCP For Potential Use as Bone Graft Material

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dc.authoridMOTAMENI, ALI/0000-0001-7400-9890
dc.authoridAlshemary, Ammar Z/0000-0001-5367-1869
dc.authoridDalgic, Ali Deniz/0000-0003-2904-1204
dc.authoridEvis, Zafer/0000-0002-7518-8162
dc.contributor.authorMotameni, Ali
dc.contributor.authorDalgic, Ali Deniz
dc.contributor.authorAlshemary, Ammar Z.
dc.contributor.authorKeskin, Dilek
dc.contributor.authorEvis, Zafer
dc.date.accessioned2024-09-29T16:00:27Z
dc.date.available2024-09-29T16:00:27Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractIn this study, mesoporous particles of beta-tricalcium phosphate (beta TCP, beta Ca-3(PO4)(2)) and lanthanum (La) doped beta TCP were synthesized using wet precipitation method attached with microwave refluxing system. The obtained materials were characterized and analysed using different sort of techniques such; X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscope (SEM), Inductively coupled plasma optical emission spectroscopy (ICP-OES), Brunauer-Emmett-Teller (BET) and helium pycnometer. With incorporation of La3+ ions, relevant expansion in lattice parameters of beta TCP crystal was observed along with inhibition growth rate was observed. beta TCP and La-beta TCP materials were mesoporous in nature, pore diameter and pore volume were expanded with incorporation of La3+ ions. The loading/release on beta TCP and La-beta TCP particles surfaces were evaluated using fetal bovine serum (FBS) proteins. In vitro cell culture studies were performed with human osteosarcoma cell line (Saos-2). The outcomes approved that all La-beta TCP materials were cytocompatible and strict dose dependent effect of La3+ ions was observed on cell viability and alkaline phosphatase (ALP) activity. These results strongly suggest that La-beta TCP materials have a potential application in bone tissue engineering.en_US
dc.identifier.doi10.1016/j.mtcomm.2020.101151
dc.identifier.issn2352-4928
dc.identifier.scopus2-s2.0-85083590584en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.mtcomm.2020.101151
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5162
dc.identifier.volume23en_US
dc.identifier.wosWOS:000536945200002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMaterials Today Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbeta-Tricalcium phosphateen_US
dc.subjectLanthanumen_US
dc.subjectMesoporous particlesen_US
dc.subjectIn vitro degradationen_US
dc.subjectBone graft materialsen_US
dc.titleStructural and Biological Analysis of Mesoporous Lanthanum Doped ?TCP For Potential Use as Bone Graft Materialen_US
dc.typeArticleen_US

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