Aortic stiffness increases in proportion to the severity of apnoea–hypopnea index in patients with obstructive sleep apnoea syndrome

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dc.contributor.authorÇörtük, M.
dc.contributor.authorAkyol, S.
dc.contributor.authorBaykan, A.O.
dc.contributor.authorKiraz, K.
dc.contributor.authorUçar, H.
dc.contributor.authorÇayli, M.
dc.contributor.authorKandis, H.
dc.date.accessioned2024-09-29T16:16:38Z
dc.date.available2024-09-29T16:16:38Z
dc.date.issued2016
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground and Aims: Obstructive sleep apnoea syndrome (OSA) and aortic stiffness are associated with an increased risk of cardiovascular morbidity and mortality. Although aortic stiffness increased in patients with OSA, the relationship between severity of OSA indicated with apnoea–hypopnea index (AHI) and aortic stiffness was not investigated in previous studies. The aim of this study is to investigate the relationship between the severity of OSA and aortic stiffness. Methods: In the present study, 90 consecutive OSA patients definite diagnosed with sleep test were prospectively included (mean age 54.5 ± 11.6 years). Aortic pulse wave velocity (PWV) and augmentation index (AIx) were calculated using the single-point method via the Mobil-O-Graph® ARCsolver algorithm. Aortic distensibility (AD) was calculated from the echocardiographically derived ascending aorta diameters and haemodynamic pressure measurements. Overnight full-laboratory polysomnography examination was conducted on each subject. Patients were classified into two groups according to their median AHI values (AHIlow and AHIhigh groups). Results: PWV values were higher and AD values were lower in AHIhigh group compared with AHIlow group (P < 0.05, for all). AHI was associated with body mass index (BMI), systolic blood pressure, pulse pressure, aortic diameter, AD, AIx and PWV in bivariate analysis (P < 0.05, for all). Multivariate linear regression analysis showed that AHI was independently associated with BMI (? = 0.175, P = 0.047), PWV (? = 0.521, P < 0.001) and aortic distensibility (? = ?0.223, P = 0.020). Conclusions: Aortic stiffness is associated both with the presence and the severity of OSA. © 2014 John Wiley & Sons Ltden_US
dc.identifier.doi10.1111/crj.12244
dc.identifier.endpage461en_US
dc.identifier.issn1752-6981
dc.identifier.issue4en_US
dc.identifier.pmid25401950en_US
dc.identifier.scopus2-s2.0-84978661441en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage455en_US
dc.identifier.urihttps://doi.org/10.1111/crj.12244
dc.identifier.urihttps://hdl.handle.net/20.500.14619/9239
dc.identifier.volume10en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Publishing Ltden_US
dc.relation.ispartofClinical Respiratory Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectaortaen_US
dc.subjectobstructive sleep apnoeaen_US
dc.subjectpulse wave velocityen_US
dc.subjectvascular stiffnessen_US
dc.titleAortic stiffness increases in proportion to the severity of apnoea–hypopnea index in patients with obstructive sleep apnoea syndromeen_US
dc.typeArticleen_US

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