Permeability and fluid flow-induced wall shear stress of bone tissue scaffolds: Computational fluid dynamic analysis using Newtonian and non-Newtonian blood flow models

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dc.authoridAli, Daver/0000-0002-8500-7820
dc.contributor.authorAli, Davar
dc.contributor.authorSen, Sadri
dc.date.accessioned2024-09-29T15:55:10Z
dc.date.available2024-09-29T15:55:10Z
dc.date.issued2018
dc.departmentKarabük Üniversitesien_US
dc.description.abstractAmong the factors that are important in successful bone tissue regeneration through scaffolds are permeability and fluid flow-induced wall shear stress (WSS) because of the direct contribution of these factors to cell bioactivities. The permeability of scaffolds is usually measured using fluids such as water, which are characterized as Newtonian materials with constant viscosity. However, using the fluid properties of blood as bases in measuring permeability can lead to more realistic results given that scaffolds are implanted in the body, where the only flowing fluid (i.e., blood) is a non-Newtonian fluid. Moreover, the linear relationship of WSS with fluid viscosity challenges the use of Newtonian fluids in determining WSS magnitude. With consideration for these issues, we investigated permeability and WSS through computational fluid dynamics (CFD) analyses of lattice based and gyroid scaffold architectures with Newtonian and non-Newtonian blood flow properties. With reference to geometrical parameters and the pressure drops derived from the CFD analyses, the permeability levels of the Newtonian and non-Newtonian models were calculated by exploiting the classic and modified Darcy's equations, respectively. Results showed that both scaffold architectures were several times more permeable in the Newtonian blood flow models than in their non-Newtonian counterparts. Within the scaffolds, the non Newtonian flow of blood caused almost twice the magnitude of WSS originating from Newtonian blood flow. These striking discrepancies in permeability and WSS between the two blood models were due to differences in their viscosity behaviors.en_US
dc.identifier.doi10.1016/j.compbiomed.2018.06.017
dc.identifier.endpage208en_US
dc.identifier.issn0010-4825
dc.identifier.issn1879-0534
dc.identifier.pmid29957377en_US
dc.identifier.scopus2-s2.0-85048856494en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage201en_US
dc.identifier.urihttps://doi.org/10.1016/j.compbiomed.2018.06.017
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4508
dc.identifier.volume99en_US
dc.identifier.wosWOS:000442978700019en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofComputers in Biology and Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone tissue scaffoldsen_US
dc.subjectNan-Newtonian blood modelen_US
dc.subjectPower law modelen_US
dc.subjectPermeabilityen_US
dc.subjectWall shear stressen_US
dc.subjectCFD analysisen_US
dc.titlePermeability and fluid flow-induced wall shear stress of bone tissue scaffolds: Computational fluid dynamic analysis using Newtonian and non-Newtonian blood flow modelsen_US
dc.typeArticleen_US

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