Characterization of serum N-glycome alterations in seasonal allergic rhinitis using MALDI-TOF-MS: A pilot study

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dc.authoridSalih, Bekir/0000-0002-8542-6531
dc.authoridYAMAN, MEHMET EMRAH/0000-0002-8406-7653
dc.contributor.authorYaman, Mehmet Emrah
dc.contributor.authorAvci, Izzet
dc.contributor.authorAtila, Nihal Efe
dc.contributor.authorAtila, Alptug
dc.contributor.authorKayili, Haci Mehmet
dc.contributor.authorSalih, Bekir
dc.date.accessioned2024-09-29T16:02:42Z
dc.date.available2024-09-29T16:02:42Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractSeasonal allergic rhinitis (SAR) is an inflammatory process. In this pilot study, matrix assisted laser desorption ionization-mass spectrometry (MALDI-MS)-based analyses were conducted to investigate the effects of SAR on serum N-glycome in a small dataset (n = 10 for both SAR patients and controls). It was detected that two N-glycan compositions (H6N5E2L1 and H6N5E1L2) were down-regulated in SAR patients. Additionally, five tri-antennary N-glycan traits, including both galactosylated and sialylated (A3GS and A3GL) and non-fucosylated (A3F0GE, A3F0GL, A3F0GS) ones, were decreased. Furthermore, three high-antennary and fucosylated N-glycan traits (A3F, A3EF and A4F) were increased in SAR patients compared to controls.en_US
dc.description.sponsorshipMinistry of Development-Republic of Turkey [2016 K121230]; Turkish Academy of Science (TUBA)en_US
dc.description.sponsorshipThis work was partly supported by Ministry of Development-Republic of Turkey with the project Number: 2016 K121230. Bekir Salih gratefully acknowledges the Turkish Academy of Science (TUBA) for the partial financial support.en_US
dc.identifier.doi10.1080/07328303.2021.2009502
dc.identifier.endpage282en_US
dc.identifier.issn0732-8303
dc.identifier.issn1532-2327
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85120871943en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage269en_US
dc.identifier.urihttps://doi.org/10.1080/07328303.2021.2009502
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5670
dc.identifier.volume40en_US
dc.identifier.wosWOS:000725432500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Carbohydrate Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGlycomicsen_US
dc.subjectMALDI-TOF-MSen_US
dc.subjectmass spectrometryen_US
dc.subjectseasonal Allergic rhinitis (SAR)en_US
dc.subjectserum N-glycosylationen_US
dc.titleCharacterization of serum N-glycome alterations in seasonal allergic rhinitis using MALDI-TOF-MS: A pilot studyen_US
dc.typeArticleen_US

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