Exploring how Family and Neighborhood Stressors Influence Genetic Risk for Adolescent Conduct Problems and Alcohol Use

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dc.authoridMustanski, Brian/0000-0001-9222-5116
dc.authoridKarriker-Jaffe, Katherine/0000-0002-2019-0222
dc.authoridChartier, Karen/0000-0002-2410-2584
dc.contributor.authorBares, Cristina B.
dc.contributor.authorChartier, Karen G.
dc.contributor.authorKarriker-Jaffe, Katherine J.
dc.contributor.authorAliev, Fazil
dc.contributor.authorMustanski, Brian
dc.contributor.authorDick, Danielle
dc.date.accessioned2024-09-29T15:51:19Z
dc.date.available2024-09-29T15:51:19Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractPrevious research suggests that genetic risk factors may predispose to conduct problems and alcohol use in adolescence. Whether genetic risk factors interact with social contexts has not been well characterized among African American adolescents. Data came from a subsample of the Genes, Environment, and Neighborhood Initiative study comprising 501 African American adolescents, including 151 lifetime drinkers (56% female, mean age = 16.3, SD = 1.4). Genetic risk was assessed with polygenic risk scores for alcohol dependence. Analyses explored interactions between genetic risk and self-reported alcohol use, conduct problems, life stressors, and other covariates. The effects of two gene-environment interactions (G x E) were tested in the sample of alcohol exposed adolescents; one on conduct problems and the other on alcohol use. There were significant associations between polygenic risk for alcohol dependence and conduct problems. A significant G x E interaction showed the impact of genetic risk on conduct problems was stronger under conditions of high exposure to family and neighborhood stressors. Among this sample of African American adolescents, genetic risk for alcohol dependence was not directly associated with alcohol use but was related to more conduct problems. Further, the effect of genetic risk interacted with stressors from the family and neighborhood, so that the effect of genetic risk on conduct problems was stronger for individuals who reported greater stressors.en_US
dc.identifier.doi10.1007/s10964-019-01098-9
dc.identifier.endpage1378en_US
dc.identifier.issn0047-2891
dc.identifier.issn1573-6601
dc.identifier.issue7en_US
dc.identifier.pmid31407187en_US
dc.identifier.scopus2-s2.0-85070855936en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1365en_US
dc.identifier.urihttps://doi.org/10.1007/s10964-019-01098-9
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4010
dc.identifier.volume49en_US
dc.identifier.wosWOS:000540516900002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofJournal of Youth and Adolescenceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectConduct problemsen_US
dc.subjectAlcohol useen_US
dc.subjectGenetic risken_US
dc.subjectExposure to stressorsen_US
dc.subjectAdolescentsen_US
dc.titleExploring how Family and Neighborhood Stressors Influence Genetic Risk for Adolescent Conduct Problems and Alcohol Useen_US
dc.typeArticleen_US

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