Investigation of wet cupping therapy's effect on oxidative stress based on biochemical parameters

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dc.authoridBenli, Ali Ramazan/0000-0003-0039-1497
dc.authoridengin, velittin selcuk/0000-0002-6338-4748
dc.authoridErsoy, Suleyman/0000-0003-0001-9329
dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.contributor.authorErsoy, Suleyman
dc.contributor.authorAltinoz, Eyup
dc.contributor.authorBenli, Ali Ramazan
dc.contributor.authorErdemli, Mehmet Erman
dc.contributor.authorAksungur, Zeynep
dc.contributor.authorBag, Harika Gozukara
dc.contributor.authorEngin, Velittin Selcuk
dc.date.accessioned2024-09-29T15:57:10Z
dc.date.available2024-09-29T15:57:10Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractIntroduction: Wet cupping therapy is one of the main applications which has been used in the Unani medicine system. Current literature explaining how this traditional treatment method works is still limited. The aim of this study was to investigate whether wet cupping therapy could affect reactive oxygen species and antioxidant levels. Methods: This was a single arm pre and posttest intervention study conducted in Karabuk University Teaching and Research Hospital (KUTRH) between 1st January and 1st May 2018. Twenty-four participants were included. Wet Cupping Therapy was applied to all individuals once every month for three months. Venous blood samples were collected before the first (Venousl) and after the last application (Venous 2) and cupping blood samples were collected during the first and last applications. Malondialdehyde (MAD) and total oxidant status (TOS) which both indicate oxidation; glutathione (GSH), superoxide dismutase (SOD), total antioxidant status (TAS), catalase (CAT) activities that indicate antioxidant effect, and protein levels were measured on the obtained serums. Results: The highest MDA and TOS levels and the lowest TAS, GSH, SOD and CAT levels were found in initial cupping blood. Significant improvement was observed in second cupping blood for these parameters when compared to initial values. We also found that MDA and TOS levels, as well as TAS, GSH, SOD and CAT levels, all changed favorably in the Venous 2 blood sample compared to the Venous 1 (p < 0.001). Conclusion: Wet cupping therapy seems a promising method for increasing antioxidant levels and curbing oxidative stress.en_US
dc.identifier.doi10.1016/j.eujim.2019.100946
dc.identifier.issn1876-3820
dc.identifier.issn1876-3839
dc.identifier.scopus2-s2.0-85069969285en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.eujim.2019.100946
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4634
dc.identifier.volume30en_US
dc.identifier.wosWOS:000492842100010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofEuropean Journal of Integrative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectWet cupping therapyen_US
dc.subjectOxidative stressen_US
dc.subjectMalondialdehydeen_US
dc.subjectGlutathioneen_US
dc.subjectTotal oxidant statusen_US
dc.titleInvestigation of wet cupping therapy's effect on oxidative stress based on biochemical parametersen_US
dc.typeArticleen_US

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