Evaluation of the effects of bone morphogenetic protein-2 on the healing of bone calvarial defects in ovariectomized rats

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dc.authoridKarayurek, Fatih/0000-0003-0602-7610
dc.contributor.authorKadiroglu, Ela Tules
dc.contributor.authorKarayurek, Fatih
dc.contributor.authorAkbalik, Mehmet Erdem
dc.date.accessioned2024-09-29T16:08:22Z
dc.date.available2024-09-29T16:08:22Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBone morphogenetic proteins (BMPs) are often used with bone grafts for bone regeneration. The aim of this study was to evaluate the effect of demineralized freeze-dried bone allografts and externally applied rhBMP-2 on bone healing in experimentally generated defects in the calvarium of ovariectomized and nonovariectomized rats via histological and immunohistochemical assays. The current study was carried out on 42 female Wistar rats. After ovariectomy was performed in half of the rats, the rats were divided into three groups: control, allograft, and allograft + BMP. An experimental defect with a diameter of 4 mm was created unilaterally in the parietal bone using a trephine dental drill and a physiodispenser with saline. All animals were euthanized at the end of week 8, and bone tissues were analyzed histologically and immunohistochemically. The allografts produced better results in terms of calvarial defect healing in both the ovariectomized and nonovariectomized groups compared to the control group in enhancing bone healing, whereas BMPs combined with allografts had no positive effect on new bone formation. The allografts and BMPs applied in both groups produced fibrous tissues rather than new bone tissue. Further comprehensive studies on the effectiveness of BMPs in the formation of new bone tissue should be conducted in animals with estrogen deficiency.en_US
dc.description.sponsorshipDicle University Scientific Research Projects Office [12-DH-53]en_US
dc.description.sponsorshipWe would like to thank Dicle University for its contributions. This study was supported by the Dicle University Scientific Research Projects Office (12-DH-53).en_US
dc.identifier.doi10.3906/vet-1911-24
dc.identifier.endpage561en_US
dc.identifier.issn1300-0128
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85084312400en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage548en_US
dc.identifier.trdizinid353915en_US
dc.identifier.urihttps://doi.org/10.3906/vet-1911-24
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/353915
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7513
dc.identifier.volume44en_US
dc.identifier.wosWOS:000538112800010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Veterinary & Animal Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBone morphogenetic proteinen_US
dc.subjectallograften_US
dc.subjectovariectomyen_US
dc.subjectbone regenerationen_US
dc.subjectraten_US
dc.titleEvaluation of the effects of bone morphogenetic protein-2 on the healing of bone calvarial defects in ovariectomized ratsen_US
dc.typeArticleen_US

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