Nonsurgical periodontal therapy with/without diode laser modulates metabolic control of type 2 diabetics with periodontitis: a randomized clinical trial

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dc.contributor.authorKoçak, E.
dc.contributor.authorSaglam, M.
dc.contributor.authorKayis, S.A.
dc.contributor.authorDündar, N.
dc.contributor.authorKebapçilar, L.
dc.contributor.authorG.Loos, B.
dc.contributor.authorHakki, S.S.
dc.date.accessioned2024-09-29T16:21:13Z
dc.date.available2024-09-29T16:21:13Z
dc.date.issued2016
dc.departmentKarabük Üniversitesien_US
dc.description.abstractIn order to evaluate whether nonsurgical periodontal treatment with/without diode laser (DL) decontamination improves clinical parameters, the levels of IL-1?, IL-6, IL-8, intercellular adhesion molecule (ICAM), and vascular cell adhesion molecule (VCAM) in gingival crevicular fluid and metabolic control (HbA1c) in chronic periodontitis (CP) patients with diabetes mellitus type 2 (DM2). Sixty patients with DM2 and CP were randomly assigned into two groups to receive scaling and root planing (SRP, n = 30) or SRP followed by diode laser application (SRP + DL, n = 30). Clinical periodontal and gingival crevicular fluid (GCF) parameters were assessed at baseline, 1, and 3 months after periodontal treatment. HbA1c levels were evaluated at baseline and 3 months post-therapy. Total amounts of cytokines and molecules were analyzed by ELISA. Nonsurgical periodontal treatment with/without DL appeared to improve clinical, biochemical parameters, and glycemic control in DM2 patients (BMI < 25 kg/m2) with CP. The SRP + DL group provided better reductions in probing depth (PD) and clinical attachment level (CAL) parameters compared to the SRP group (P < 0.05). Significant reductions were found in the total amounts of GCF levels of IL-1, IL-6, IL-8, ICAM, and VCAM after treatment (P < 0.05). HbA1c levels decreased significantly at 3 months after treatment (P < 0.05). SRP + DL reduced HbA1c levels more significantly compared to SRP alone (0.41 vs. 0.22 %, P < 0.05). SRP, especially in combination with DL, shows improvement of glycemic control for DM2 patients with CP. © 2016, Springer-Verlag London.en_US
dc.description.sponsorshipSelcuk University, (11202014); Universiteit van Amsterdam, UvA; Türkiye Bilimsel ve Teknolojik Araştirma Kurumu, TÜBITAK, (TUBITAK/SBAG-114S229)en_US
dc.identifier.doi10.1007/s10103-016-1868-0
dc.identifier.endpage353en_US
dc.identifier.issn0268-8921
dc.identifier.issue2en_US
dc.identifier.pmid26754181en_US
dc.identifier.scopus2-s2.0-84957433270en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage343en_US
dc.identifier.urihttps://doi.org/10.1007/s10103-016-1868-0
dc.identifier.urihttps://hdl.handle.net/20.500.14619/9623
dc.identifier.volume31en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Londonen_US
dc.relation.ispartofLasers in Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCell adhesion moleculesen_US
dc.subjectChronic periodontitisen_US
dc.subjectCytokinesen_US
dc.subjectDiabetes mellitusen_US
dc.subjectDiode lasersen_US
dc.subjectMetabolic controlen_US
dc.subjectNonsurgical periodontal debridementen_US
dc.titleNonsurgical periodontal therapy with/without diode laser modulates metabolic control of type 2 diabetics with periodontitis: a randomized clinical trialen_US
dc.typeArticleen_US

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