The morphometrical and immunohistochemical investigation of the effect of topiramate on liver and the role of neuropeptide Y receptor in an obese female rat

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dc.contributor.authorYahyazadeh, A.
dc.contributor.authorAltunkaynak, B. Z.
dc.contributor.authorAlkan, I
dc.date.accessioned2024-09-29T16:08:29Z
dc.date.available2024-09-29T16:08:29Z
dc.date.issued2020
dc.departmentKarabük Üniversitesien_US
dc.description.abstractOBJECTIVE: We aimed to investigate the possible effect of topiramate (TOP, 0.02 mg/kg/day) on the livers in a high-fat diet (HFD)-induced obesity rat model. The other objective was to evaluate the relationship between TOP administration and NPY level using anti-NPY1R antibody. METHODS: Twenty-four adult female Wistar albino rats were randomly assigned into four equal groups as follow: control (CONT), obese (OBS), TOP, and OBS+TOP. All liver samples were investigated using the stereological analysis, as well as immunohistochemical and histopathological examination. RESULTS: The total number of hepatocytes was significantly decreased in the OBS+TOP group compared to the CONT group or the OBS group (p < 0.05). We found a significant increase in the mean volume of liver in the OBS group compared to the CONT group (p < 0.05). Also, the mean volume of liver was significantly decreased in the OBS+TOP group compared to the OBS group (p < 0.05). CONCLUSION: Taken together, our findings suggest that decreased liver volume is possibly attributed to TOP administration via setting the NPY level in the obese rats. Further, the side effects of TOP in combination with health risk of obesity may have led to an increase in hepatotoxicity and the subsequent hepatocyte loss (Fig. 7, Ref. 56). Text in PDF www.elis.sken_US
dc.description.sponsorshipOndokuz Mayis University Project Management Office [TIP.1904.13.024]en_US
dc.description.sponsorshipThis work was supported by the Ondokuz Mayis University Project Management Office (TIP.1904.13.024).en_US
dc.identifier.doi10.4149/BLL_2020_108
dc.identifier.endpage662en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue9en_US
dc.identifier.pmid32990014en_US
dc.identifier.scopus2-s2.0-85090941486en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage656en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2020_108
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7575
dc.identifier.volume121en_US
dc.identifier.wosWOS:000571576000007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectimmunohistochemistryen_US
dc.subjectliveren_US
dc.subjectneuropeptide Yen_US
dc.subjectobesityen_US
dc.subjectraten_US
dc.subjecttopiramateen_US
dc.titleThe morphometrical and immunohistochemical investigation of the effect of topiramate on liver and the role of neuropeptide Y receptor in an obese female raten_US
dc.typeArticleen_US

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