The Associations Between Polygenic Risk, Sensation Seeking, Social Support, and Alcohol Use in Adulthood

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dc.authoridSu, Jinni/0000-0002-9767-1489
dc.authorid/0000-0003-2291-6880
dc.authoridChan, Grace/0000-0002-1257-6889
dc.authoridEdenberg, Howard/0000-0003-0344-9690
dc.contributor.authorSu, Jinni
dc.contributor.authorKuo, Sally I-Chun
dc.contributor.authorAliev, Fazil
dc.contributor.authorChan, Grace
dc.contributor.authorEdenberg, Howard J.
dc.contributor.authorKamarajan, Chella
dc.contributor.authorMcCutcheon, Vivia V.
dc.date.accessioned2024-09-29T16:01:01Z
dc.date.available2024-09-29T16:01:01Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractGenetic predispositions play an important role in alcohol use. Understanding the psychosocial mechanisms through which genetic risk unfolds to influence alcohol use outcomes is critical for identifying modifiable targets and developing prevention and intervention efforts. In this study, we examined the role of sensation seeking and social support from family and friends in linking genetic risk to alcohol use. We also examined the role of social support in moderating the associations between genetic risk and sensation seeking and alcohol use. Data were drawn from a sample of 2,836 European American adults from the Collaborative Study on the Genetics of Alcoholism (46% male, mean age = 35.65, standard deviation [SD] = 10.78). Results from path analysis indicated that genome-wide polygenic scores for alcohol consumption (alc-GPS) were associated with higher sensation seeking, which in turn was associated with higher levels of alcohol use. alc-GPS was also associated with higher alcohol use indirectly via lower levels of family support. In addition, high friend support attenuated the association between alc-GPS and sensation seeking and alcohol use. The pattern of associations was similar for males and females, with some differences in the associations between social support and alcohol use observed across age. Our findings highlight the important role of intermediate phenotypes and gene-environment interplay in the pathways of risk from genetic predispositions to complex alcohol use outcomes.en_US
dc.description.sponsorshipNational Institutes of Health (NIH) from the NIAAA [U10AA008401]; National Institute on Drug Abuseen_US
dc.description.sponsorshipThe authors acknowledge the Collaborative Study on the Genetics of Alcoholism (COGA), Principal Investigators (PIs) B. Porjesz, V. Hesselbrock, T. Foroud; Scientific Director A. Agrawal; Translational Director Danielle M. Dick, which includes 11 different centers: University of Connecticut (V. Hesselbrock); Indiana University (Howard J. Edenberg, T. Foroud, J. Nurnberger Jr., Y. Liu); University of Iowa (S. Kuperman, J. Kramer); SUNY Downstate (B. Porjesz, Jacquelyn L. Meyers, Chella Kamarajan, A. Pandey); Washington University in St. Louis (L. Bierut, J. Rice, K. Bucholz, A. Agrawal); University of California at San Diego (Marc Schuckit); Rutgers University (Jay Tischfield, A. Brooks, R. Hart); the Children's Hospital of Philadelphia, the University of Pennsylvania (L. Almasy); Virginia Commonwealth University (Danielle M. Dick, J. Salvatore); Icahn School of Medicine at Mount Sinai (A. Goate, M. Kapoor, P. Slesinger); and Howard University (D. Scott). Other COGA collaborators include L. Bauer (University of Connecticut); L. Wetherill, X. Xuei, D. Lai, S. O'Connor, M. Plawecki, S. Lourens (Indiana University); L. Acion (University of Iowa); Grace Chan (University of Iowa; University of Connecticut); D. B. Chorlian, J. Zhang, S. Kinreich, G. Pandey (State University of New York Downstate); M. Chao (Icahn School of Medicine at Mount Sinai); A. Anokhin, Vivia V. McCutcheon, S. Saccone (Washington University); Fazil Aliev, P. Barr (Virginia Commonwealth University); H. Chin and A. Parsian are the National Institute on Alcohol Abuse and Alcoholism (NIAAA) staff collaborators. We continue to be inspired by our memories of Henri Begleiter and Theodore Reich, founding PI and co-PI of COGA, and also owe a debt of gratitude to other past organizers of COGA, including Ting-Kai Li, P. Michael Conneally, Raymond Crowe, and Wendy Reich, for their critical contributions. This national collaborative study was supported by National Institutes of Health (NIH) Grant U10AA008401 from the NIAAA and the National Institute on Drug Abuse.en_US
dc.identifier.doi10.1037/abn0000568
dc.identifier.endpage536en_US
dc.identifier.issn0021-843X
dc.identifier.issn1939-1846
dc.identifier.issue5en_US
dc.identifier.pmid34472888en_US
dc.identifier.scopus2-s2.0-85117623429en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage525en_US
dc.identifier.urihttps://doi.org/10.1037/abn0000568
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5489
dc.identifier.volume130en_US
dc.identifier.wosWOS:000692685500009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Psychological Assocen_US
dc.relation.ispartofJournal of Abnormal Psychologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectpolygenic scoresen_US
dc.subjectsensation seekingen_US
dc.subjectsocial supporten_US
dc.subjectalcohol useen_US
dc.subjectgene-environment interplayen_US
dc.titleThe Associations Between Polygenic Risk, Sensation Seeking, Social Support, and Alcohol Use in Adulthooden_US
dc.typeArticleen_US

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