There is no evidence of cochlear and vestibular melanocyte damage in patients with alopecia areata

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dc.authoridERTUGRUL, SUHA/0000-0001-9743-6924
dc.authoridSOYLEMEZ, EMRE/0000-0002-7554-3048
dc.contributor.authorErtugrul, Goksen
dc.contributor.authorErtugrul, Suha
dc.contributor.authorSoylemez, Emre
dc.date.accessioned2024-09-29T16:04:40Z
dc.date.available2024-09-29T16:04:40Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractPurpose Follicular melanocytes are known to be damaged in alopecia areata (AA). However, it is not clear whether melanocytes are the primary target of autoimmunity and whether melanocytes in the inner ear are affected. This study aimed to detect possible cochlear and/or vestibular melanocyte damage in AA patients. Methods Thirty-two AA patients and 35 sex- and age-matched healthy volunteers were evaluated between November 2018 and March 2020 at the Karabuk University Training and Research Hospital. The conventional pure tone audiometry test and distortion product otoacoustic emission test were performed to evaluate hearing. To evaluate the vestibular function, the following tests were performed: the vestibulospinal reflex tests (Romberg test, tandem stance test and tandem walking test); positional balance tests (Dix-Hallpike test, supine roll test and head hanging test); vestibulo-ocular reflex tests (caloric test, head shake test) and oculomotor tests (saccade, smooth pursuit and optokinetic). Results The mean age of AA patients was 31.94 +/- 11.86 years (range, 15-67 years). There were no significant differences in the results of the hearing and balance tests between the groups. Furthermore, disease parameters (duration of the last attack, recurrence, positive family history, positive pull test, the severity of the disease, etc) were not associated with hearing loss and vestibular damage. Conclusion AA patients did not exhibit hearing loss or balance abnormalities that would indicate cochlear and vestibular melanocyte damage. The lack of damage to the inner ear melanocytes in AA patients may indicate that follicular melanocytes are affected secondary to autoimmune damage in the hair bulb, and melanocytes are not the primary target in the pathogenesis of AA.en_US
dc.identifier.doi10.1111/ijcp.14040
dc.identifier.issn1368-5031
dc.identifier.issn1742-1241
dc.identifier.issue5en_US
dc.identifier.pmid33484073en_US
dc.identifier.scopus2-s2.0-85099907916en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/ijcp.14040
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6244
dc.identifier.volume75en_US
dc.identifier.wosWOS:000612141500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Hindawien_US
dc.relation.ispartofInternational Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSensorineural Hearing-Lossen_US
dc.subjectAbnormalitiesen_US
dc.titleThere is no evidence of cochlear and vestibular melanocyte damage in patients with alopecia areataen_US
dc.typeArticleen_US

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