Effects of acorus calamus plant extract on prostate cancer cell culture
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In western countries,prostate cancer is the most frequently diagnosed cancer and the second mostcommon cause of death from cancer in men. Vascular endothelial growth factor-A(VEGF-A), thought to be the single most important angiogenic factor in prostatcancer. Poly-(ADP-ribose) polymerase (PARP) involved in apoptotic process andcleavage of PARP serves as a marker of cells undergoing apoptosis. Acorus calamus have long been consideredto have anti-carcinogenic and medicinal properties especially in Asia. Weexamined whether ethanolic extract of A.calamus root affects the survival of prostate cancer LNCaP cells andinduces apoptosis and angiogenesis of these cells in vitro. Cells were incubated during 24 and 48 hours with variousdoses of extract. Extract with these concentrations reduced the number of LNCaPliving cells up to 44 % as compared to the control at dose and time dependentmanner at 24 and 48 hours. Significantly alterations were observed at cleavedPARP, VEGF-A protein and gene expression amounts after 24 and 48 hours. Thepresent study reveals the possibility that ethanolic extract of A. calamus root posseses a dose and timedependent anticancer, apoptotic and anti-angiogenic properties.
Açıklama
Anahtar Kelimeler
Kaynak
Anatolian Journal of Botany
WoS Q Değeri
Scopus Q Değeri
Cilt
2
Sayı
1
