Effects of acorus calamus plant extract on prostate cancer cell culture

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dc.contributor.authorKoca, Halit Buğra
dc.contributor.authorKöken, Tülay
dc.contributor.authorÖzkurt, Mete
dc.contributor.authorKuş, Gökhan
dc.contributor.authorKabadere, Selda
dc.contributor.authorErkasap, Nilüfer
dc.contributor.authorKoca, Oğuzhan
dc.date.accessioned2024-09-29T16:30:45Z
dc.date.available2024-09-29T16:30:45Z
dc.date.issued2018
dc.departmentKarabük Üniversitesien_US
dc.description.abstractIn western countries,prostate cancer is the most frequently diagnosed cancer and the second mostcommon cause of death from cancer in men. Vascular endothelial growth factor-A(VEGF-A), thought to be the single most important angiogenic factor in prostatcancer. Poly-(ADP-ribose) polymerase (PARP) involved in apoptotic process andcleavage of PARP serves as a marker of cells undergoing apoptosis. Acorus calamus have long been consideredto have anti-carcinogenic and medicinal properties especially in Asia. Weexamined whether ethanolic extract of A.calamus root affects the survival of prostate cancer LNCaP cells andinduces apoptosis and angiogenesis of these cells in vitro. Cells were incubated during 24 and 48 hours with variousdoses of extract. Extract with these concentrations reduced the number of LNCaPliving cells up to 44 % as compared to the control at dose and time dependentmanner at 24 and 48 hours. Significantly alterations were observed at cleavedPARP, VEGF-A protein and gene expression amounts after 24 and 48 hours. Thepresent study reveals the possibility that ethanolic extract of A. calamus root posseses a dose and timedependent anticancer, apoptotic and anti-angiogenic properties.en_US
dc.identifier.doi10.30616/ajb.391985
dc.identifier.endpage51en_US
dc.identifier.issue1en_US
dc.identifier.startpage46en_US
dc.identifier.trdizinid403231en_US
dc.identifier.urihttps://doi.org/10.30616/ajb.391985
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/403231
dc.identifier.urihttps://hdl.handle.net/20.500.14619/10865
dc.identifier.volume2en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnatolian Journal of Botanyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleEffects of acorus calamus plant extract on prostate cancer cell cultureen_US
dc.typeArticleen_US

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