Antioxidant, anti-inflammatory, and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in rats

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dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.authoridDEMIR, MEHMET/0000-0001-6990-3337
dc.contributor.authorAbdulkareem Aljumaily, Sara Asaad
dc.contributor.authorDemir, Mehmet
dc.contributor.authorElbe, Hulya
dc.contributor.authorYigitturk, Gurkan
dc.contributor.authorBicer, Yasemin
dc.contributor.authorAltinoz, Eyup
dc.date.accessioned2024-09-29T15:51:26Z
dc.date.available2024-09-29T15:51:26Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractDoxorubicin (DOX) is a well-known chemotherapeutic drug for most malignancies including breast cancer and leukemia whilst the usage of DOX is limited owing to its cardiotoxicity. In the present study, we aimed to investigate the effects of crocin on doxorubicin-induced cardiotoxicity in rats. Forty rats were randomly divided into four groups: (a) control [received normal saline as a dose of 1 ml/kg by intraperitoneal injection (ip) for 15 days], (b) crocin (received crocin as a dose of 40 mg/kg/24h by ip for 15 days), (c) DOX (received DOX as a dose of 2 mg/kg/48h by ip in six injection, cumulative dose 12 mg/kg), and (d) DOX+crocin (received DOX as a dose of 2 mg/kg/48h by ip in six injection, and crocin as a dose of 40 mg/kg/24h i.p for 15 days). As compared to the controls, the results showed that DOX administration caused significant increases in lipid indices [triglyseride (TG), low-dencity lipoproteins (LDL) (p<0.001), and very low-dencity lipoproteins (VLDL) (p<0.005)], oxidative stress parameters [malondialdehyde (MDA) and total oxidant status (TOS) (p<0.001)] and cardiac markers [creatine kinase-muscle/brain (CK-MB) and cardiac troponin I (cTnI) (p<0.001)]. Besides, significant decreases in antioxidant defense systems [glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and total antioxidant status (TAS) (p<0.001)] were observed. The present study also demonstrated that co-administration of crocin with DOX significantly ameliorated the lipid profile (p<0.005), cardiac markers (p<0.005), and oxidative stress indices (p<0.001) as compared to DOX group. Histopathologically, significant increase in the mean histopathological damage score (MHDS) was found in the DOX group as compared to the controls (p<0.001). In contrast, the administration of crocin with DOX alleviated MHDS in myocardium (p<0.001). Taken together, our results reveal that crocin might be a cardioprotective agent in DOX-treated patients for cancer.en_US
dc.description.sponsorshipKarabuk University Scientifict Research Fund [TYL-2020-2298]en_US
dc.description.sponsorshipThe research was supported by Karabuk University Scientifict Research Fund (TYL-2020-2298).en_US
dc.identifier.doi10.1007/s11356-021-15409-w
dc.identifier.endpage65813en_US
dc.identifier.issn0944-1344
dc.identifier.issn1614-7499
dc.identifier.issue46en_US
dc.identifier.pmid34322808en_US
dc.identifier.scopus2-s2.0-85111500058en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage65802en_US
dc.identifier.urihttps://doi.org/10.1007/s11356-021-15409-w
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4078
dc.identifier.volume28en_US
dc.identifier.wosWOS:000678513500039en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofEnvironmental Science and Pollution Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDoxorubicinen_US
dc.subjectcrocinen_US
dc.subjectapoptosisen_US
dc.subjectoxidative stressen_US
dc.subjectmyocardial toxicityen_US
dc.titleAntioxidant, anti-inflammatory, and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in ratsen_US
dc.typeArticleen_US

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