The Family Check-up Intervention Moderates Polygenic Influences on Long-Term Alcohol Outcomes: Results from a Randomized Intervention Trial

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dc.authoridHa, Thao/0000-0003-1498-7873
dc.contributor.authorKuo, Sally I-Chun
dc.contributor.authorSalvatore, Jessica E.
dc.contributor.authorAliev, Fazil
dc.contributor.authorHa, Thao
dc.contributor.authorDishion, Thomas J.
dc.contributor.authorDick, Danielle M.
dc.date.accessioned2024-09-29T15:51:25Z
dc.date.available2024-09-29T15:51:25Z
dc.date.issued2019
dc.departmentKarabük Üniversitesien_US
dc.description.abstractAlcohol problems are influenced by both genetic and environmental factors. Evidence from twin models and measured gene-environment interaction studies has demonstrated that the importance of genetic influences changes as a function of the environment. Research has also shown that family-centered interventions may protect genetically susceptible youth from developing substance use problems. In this study, we brought large-scale gene identification findings into an intervention study to examine gene-by-intervention effects. Using genome-wide polygenic scores derived from an independent genome-wide association study of adult alcohol dependence, we examined whether an adolescent family-centered intervention would moderate the effect of genetic risk for alcohol dependence on lifetime alcohol dependence in young adulthood, approximately 15 years after the start of intervention, among European American (N = 271; 48.3% in the intervention condition) and African American individuals (N = 192; 51.6% in the intervention condition). We found that among European American individuals, the intervention moderated the association between alcohol dependence polygenic scores and lifetime alcohol dependence diagnosis in young adulthood. Among participants in the control condition, higher alcohol dependence polygenic scores were associated with a greater likelihood of receiving an alcohol dependence diagnosis; in contrast, among participants in the intervention condition, there was no association between alcohol dependence polygenic scores and alcohol dependence diagnosis. No moderation effect was found among African Americans. These results demonstrate that modifying environments of genetically vulnerable youth could reduce the likelihood of developing alcohol dependence and underscore the significance of environmentally focused prevention and intervention efforts.en_US
dc.description.sponsorshipNational Institutes of Health (NIH) from NIAAA [R01AA022071]; National Institutes of Health (NIH) from NIDA [R01DA07031]; NIH [K02AA018755, K01AA024152]en_US
dc.description.sponsorshipThis project was supported by the National Institutes of Health (NIH) Grants R01AA022071 (PI: Dishion) from NIAAA and R01DA07031 (PI: Dishion) from NIDA. This research was also supported in part by NIH grants K02AA018755 (PI: Dick) and K01AA024152 (PI: Salvatore).en_US
dc.identifier.doi10.1007/s11121-019-01024-2
dc.identifier.endpage985en_US
dc.identifier.issn1389-4986
dc.identifier.issn1573-6695
dc.identifier.issue7en_US
dc.identifier.pmid31175564en_US
dc.identifier.scopus2-s2.0-85067230677en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage975en_US
dc.identifier.urihttps://doi.org/10.1007/s11121-019-01024-2
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4058
dc.identifier.volume20en_US
dc.identifier.wosWOS:000483624900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofPrevention Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlcohol problemsen_US
dc.subjectGene-by-interventionen_US
dc.subjectGene-by-environmenten_US
dc.subjectPolygenicen_US
dc.subjectFamily-centered interventionen_US
dc.titleThe Family Check-up Intervention Moderates Polygenic Influences on Long-Term Alcohol Outcomes: Results from a Randomized Intervention Trialen_US
dc.typeArticleen_US

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