Dentinal tubule occluding capability of nano-hydroxyapatite; The in-vitro evaluation

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dc.authoriddogan, mustafa/0000-0002-3782-8640
dc.authoridDogan, Mustafa/0000-0002-4437-566X
dc.authoridErdem, Umit/0000-0002-0480-8176
dc.contributor.authorBaglar, Serdar
dc.contributor.authorErdem, Umit
dc.contributor.authorDogan, Mustafa
dc.contributor.authorTurkoz, Mustafa
dc.date.accessioned2024-09-29T15:50:43Z
dc.date.available2024-09-29T15:50:43Z
dc.date.issued2018
dc.departmentKarabük Üniversitesien_US
dc.description.abstractIn this in-vitro study, the effectiveness of experimental pure nano-hydroxyapatite (nHAP) and 1%, 2%, and 3% F doped nano-HAp on dentine tubule occlusion was investigated. And also, the cytotoxicity of materials used in the experiment was evaluated. Nano-HAp types were synthesized by the precipitation method. Forty dentin specimens were randomly divided into five groups of; 1no treatment (control), 2specimens treated with 10% pure nano-HAp and 3, 4, 5 specimens treated with 1%, 2%, and 3% F(-)doped 10% nano-HAp, respectively. To evaluate the effectiveness of the materials used; pH, FTIR, and scanning electron microscopy evaluations were performed before and after degredation in simulated body fluid. To determine cytotoxicity of the materials, MTT assay was performed. Statistical evaluations were performed with F and t tests. All of the nano-HAp materials used in this study built up an effective covering layer on the dentin surfaces even with plugs in tubules. It was found that this layer had also a resistance to degradation. None of the evaluated nano-HAp types were have toxicity. Fluoride doping showed a positive effect on physical and chemical stability until a critical value of 1% F-. The all evaluated nano-HAp types may be effectively used in dentin hypersensitivity treatment. The formed nano-HAp layers were seem to resistant to hydrolic deletion. The pure and 1% F(-)doped nano-HAp showed the highest biocompatibility thus it was assessed that pure and 1% F(-)doped materials may be used as an active ingredient in dentin hypersensitivity agents.en_US
dc.identifier.doi10.1002/jemt.23046
dc.identifier.endpage854en_US
dc.identifier.issn1059-910X
dc.identifier.issn1097-0029
dc.identifier.issue8en_US
dc.identifier.pmid29707852en_US
dc.identifier.scopus2-s2.0-85046072305en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage843en_US
dc.identifier.urihttps://doi.org/10.1002/jemt.23046
dc.identifier.urihttps://hdl.handle.net/20.500.14619/3702
dc.identifier.volume81en_US
dc.identifier.wosWOS:000448889100005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofMicroscopy Research and Techniqueen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcytotoxicityen_US
dc.subjectdegredationen_US
dc.subjectdentine hypersensitivityen_US
dc.subjectdentine tubule occlusionen_US
dc.subjectfluorideen_US
dc.subjecthydroxyapatiteen_US
dc.titleDentinal tubule occluding capability of nano-hydroxyapatite; The in-vitro evaluationen_US
dc.typeArticleen_US

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