Neuroprotection by melatonin against acrylamide-induced brain damage in pinealectomized rats

Basit Öğe Kaydı
dc.authoridYilmaz, Umit/0000-0003-0248-3483
dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.contributor.authorBicer, Yasemin
dc.contributor.authorElbe, Hulya
dc.contributor.authorKarayakali, Melike
dc.contributor.authorYigitturk, Gurkan
dc.contributor.authorYilmaz, Umit
dc.contributor.authorCengil, Osman
dc.contributor.authorAl Gburi, Mohammed Raed Abdullah
dc.date.accessioned2024-09-29T15:57:30Z
dc.date.available2024-09-29T15:57:30Z
dc.date.issued2022
dc.departmentKarabük Üniversitesien_US
dc.description.abstractThe current study aimed to evaluate the neuroprotective effect of exogenous melatonin against acrylamide (ACR)-induced oxidative stress and inflammatory and apoptotic responses in the brain tissues in pinealectomized rats (PINX). ACR is a toxic chemical carcinogen that occurs owing to the preparation of carbohydrate-rich foods at high temperatures or other thermal processes. The rats who underwent pinealectomy and sham pinealectomy were exposed to ACR (25 mg/kg b.w., orally) alone or with exogenous melatonin (10 mg/kg b.w., i.p.) for 21 consecutive days. Alterations of brain oxidant/antioxidant status, dopamine (DA), Brain-Derived Neurotropic Factor (BDNF) inflammatory mediator and apoptosis during exposure to ACR in pinealectomized rats were more than without pinealectomized rats. Histopathological changes were more in brain tissue of pinealectomized rats after ACR administration. Exogenous melatonin treatment in ACR-exposed rats following pinealectomy increased the activities of antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT) and improved brain total antioxidant status (TAS) compared to PINX+ACR. Moreover, melatonin suppressed lipid peroxidation, inflammatory pathways and apoptosis in ACR-intoxicated brain tissues. In addition, after exposure to ACR on pinealectomized rats, melatonin treatment ameliorated BDNF and DA levels in brain tissues. Furthermore, exogenous melatonin intervention in ACR-intoxicated rats significantly rescued the architecture of neuronal tissues. In summary, the present study, for the first time, suggested that exogenous melatonin treatment could reduce oxidative damage by increasing the activities of antioxidant enzymes, inhibiting lipid peroxidation and inflammation, and improving histopathological alterations in the brain tissue of pinealectomized rats after ACR administration.en_US
dc.description.sponsorshipKarabuk University Scientific Research Department [KBUBAP-21-YL-045]en_US
dc.description.sponsorshipAcknowledgements and Funding This research was funded by Karabuk University Scientific Research Department (KBUBAP-21-YL-045) .en_US
dc.identifier.doi10.1016/j.jchemneu.2022.102143
dc.identifier.issn0891-0618
dc.identifier.issn1873-6300
dc.identifier.pmid35952951en_US
dc.identifier.scopus2-s2.0-85135898798en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.1016/j.jchemneu.2022.102143
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4826
dc.identifier.volume125en_US
dc.identifier.wosWOS:000855166100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Chemical Neuroanatomyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPinealectomyen_US
dc.subjectAcrylamideen_US
dc.subjectMelatoninen_US
dc.subjectLipid peroxidationen_US
dc.subjectNeurotoxicityen_US
dc.subjectInflammationen_US
dc.titleNeuroprotection by melatonin against acrylamide-induced brain damage in pinealectomized ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu