The effects of lycopene on methotrexate-induced liver injury in rats

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dc.authoridYUCEL, YUSUF CEM/0000-0001-6183-0129
dc.authoridBuyukaslan, Hasan/0000-0002-4714-7347
dc.contributor.authorYucel, Y.
dc.contributor.authorOguz, E.
dc.contributor.authorKocarslan, S.
dc.contributor.authorTatli, F.
dc.contributor.authorGozeneli, O.
dc.contributor.authorSeker, A.
dc.contributor.authorSezen, H.
dc.date.accessioned2024-09-29T16:08:29Z
dc.date.available2024-09-29T16:08:29Z
dc.date.issued2017
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBACKGROUND: The aim of this study was to investigate the effects of lycopene (Lyc) on methotrexate (Mtx) induced liver toxicity in rats. METHODS: Twenty-eight male Sprague-Dawley rats were divided into four equal groups: control, Lyc, Mtx and Mtx-L: Control group: Rats were given only the vehicle. Lyc group: Rats were given Lyc (10 mg/kg) with corn oil by oral gavage for ten days. Mtx group: Rats were injected intraperitoneally with a single dose of 20 mg/kg of Mtx and given corn oil by oral gavage. Mtx-L group: Rats were post-treated with Lyc (10 mg/kg) for ten days after a single dose of Mtx (20 mg/kg). RESULTS: Mtx administration increased histopathological damage, TNF-alpha, IL-1 beta, TOS, TAS and OSI levels in tissues; AST, ALT levels in the blood. Sinusoidal dilatation, inflammatory cell infiltration and congestion were significantly improved in the Mtx-L aon histopathologic examination of the rats. In Mtx-L group that were treated at the Lyc, TNF-alpha and IL-1 beta levels of liver tissue were decreased significantly compared to Mtx group whereas the decrease in OSI was not significant. Lyc treatment improved the AST and ALT values in Mtx-L group. But only AST improvement was significant. CONCLUSIONS: The results of this study revealed that Lyc might be useful in protecting the liver from injury due to Mtx in rats by reducing the increased proinflammatory cytokine levels (Tab. 4, Fig. 1, Ref. 44). Text in PDF www.elis.sk.en_US
dc.description.sponsorshipScientific Research Committee of Harran University [14111]en_US
dc.description.sponsorshipThis study was supported by a grant from Scientific Research Committee of Harran University (Grand number: 14111).en_US
dc.identifier.doi10.4149/BLL_2017_042
dc.identifier.endpage216en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue4en_US
dc.identifier.pmid28471231en_US
dc.identifier.scopus2-s2.0-85018920139en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage212en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2017_042
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7573
dc.identifier.volume118en_US
dc.identifier.wosWOS:000401303100005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectlycopeneen_US
dc.subjectliver injuryen_US
dc.subjectmethotrexateen_US
dc.subjectTNF-alphaen_US
dc.subjectIL-1 betaen_US
dc.subjectoxidative stresssen_US
dc.titleThe effects of lycopene on methotrexate-induced liver injury in ratsen_US
dc.typeArticleen_US

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