Application of response surface methodology to extract yields from stinging nettle under supercritical ethanol conditions

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dc.contributor.authorAkalin, Mehmet Kuddusi
dc.contributor.authorKaragoz, Selhan
dc.contributor.authorAkyuz, Mehmet
dc.date.accessioned2024-09-29T16:00:46Z
dc.date.available2024-09-29T16:00:46Z
dc.date.issued2013
dc.departmentKarabük Üniversitesien_US
dc.description.abstractResponse surface methodology was employed using a central composite design of experiments to optimize experimental conditions for stinging nettle extract yields under supercritical ethanol conditions. The following independent variables were investigated: extraction temperature, extraction time and plant concentration. The most significant factor was found to be the extraction temperature. A correlation coefficient was estimated to be 0.94, which demonstrates the effectiveness of the model. The values of the parameters in optimized conditions for the stinging nettle extract yield included an extraction temperature of 335 degrees C, an extraction time of 87 min, and a plant concentration of 9. A subsequent validation experiment was carried out at the optimal conditions. The validation experiment showed that the actual and predicted values for the stinging nettle extract yields were 45.3 and 42.7 wt%, respectively. The stinging nettle extracts consisted of a collection of compounds including fatty acid esters (FAE), phenols, indoles, and nitrogen containing compounds. (C) 2013 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipKarabuk University [KBU-BAP-13/1-DR-008]en_US
dc.description.sponsorshipThe authors gratefully acknowledge Karabuk University for financial support (KBU-BAP-13/1-DR-008).en_US
dc.identifier.doi10.1016/j.supflu.2013.10.004
dc.identifier.endpage172en_US
dc.identifier.issn0896-8446
dc.identifier.issn1872-8162
dc.identifier.scopus2-s2.0-84887854592en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage164en_US
dc.identifier.urihttps://doi.org/10.1016/j.supflu.2013.10.004
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5342
dc.identifier.volume84en_US
dc.identifier.wosWOS:000329682700018en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofJournal of Supercritical Fluidsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStinging nettle extracten_US
dc.subjectCentral composite designen_US
dc.subjectResponse surface methodologyen_US
dc.titleApplication of response surface methodology to extract yields from stinging nettle under supercritical ethanol conditionsen_US
dc.typeArticleen_US

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