Study on dna binding properties of nickle (ii) phthalocyanine compound with 2-isopropyl-5- methylphenoxy substituents.
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Tarih
2017
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info:eu-repo/semantics/openAccess
Özet
I n this study, previously synthesized Ni (II) phthalocyanine compound bearing 2,10,16,24-tetrakis(2-isopropyl-5-methylphenoxy group was chosen for its interaction with calf thymus-DNA. Calf thymus-DNA was used to determine DNA binding properties of Ni (II) phthalocyanine compound. The DNA binding activities of Ni (II) phthalocyanine compound bearing 2-isopropyl-5-methylphenoxy substituent was investigated by using absorption titration, fluorescence emission, cyclic voltammetry, gel elctrophoresis in Tris-HCl buffer at pH 7.0. In addition to above methods, melting point and viscosity experiment were performed to determine the DNA intercation of the compound in Tris-HCl buffer solution. The results showed that Ni (II) phthalocyanine compound binds strongly to calf thymus-DNA via intercalation binding
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Kaynak
Hittite Journal of Science and Engineering
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Cilt
4
Sayı
2
