Centrifugally spun hydroxyapatite/carbon composite nanofiber scaffolds for bone tissue engineering

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dc.authoridAkgul, Yasin/0000-0001-5643-5968
dc.contributor.authorAkgul, Yasin
dc.contributor.authorStojanovska, Elena
dc.contributor.authorCalisir, Mehmet Durmus
dc.contributor.authorPolat, Yusuf
dc.contributor.authorKilic, Ali
dc.date.accessioned2024-09-29T16:03:05Z
dc.date.available2024-09-29T16:03:05Z
dc.date.issued2024
dc.departmentKarabük Üniversitesien_US
dc.description.abstractIn recent years, advancements in tissue engineering have demonstrated the potential to expedite bone matrix formation, leading to shorter recovery times and decreased clinical challenges compared to conventional methods. Therefore, this study aims to develop composite carbon nanofibers (CNFs) integrated with nano-hydroxyapatite (nHA) particles as scaffolds for bone tissue engineering applications. A key strategy in achieving this objective involves harnessing nanofibrous structures, which offer a high surface area, coupled with nHA particles expected to accelerate bone regeneration and enhance biological activity. To realize this, polyacrylonitrile (PAN)/nHA nanofibers were fabricated using the centrifugal spinning (C-Spin) technique and subsequently carbonized to yield CNF/nHA composite structures. Scanning Electron Microscopy (SEM) confirmed C-Spin as a suitable method for PAN and CNF nanofiber production, with nHA particles uniformly dispersed throughout the nanofibrous structure. Carbonization resulted in reduced fiber diameter due to thermal decomposition and shrinkage of PAN molecules during the process. Furthermore, the incorporation of nHA particles into PAN lowered the stabilization temperature (by 5 degrees C-20 degrees C). Tensile tests revealed that PAN samples experienced an approximately 80% increase in ultimate tensile strength and a 187% increase in modulus with a 5 wt.% nHA loading. However, following carbonization, CNF samples exhibited a 50% decrease in strength compared to PAN samples. Additionally, the addition of nHA into CNF improved the graphitic structure. The incorporation of nHA particles into the spinning solution represents a viable strategy for enhancing CNF bioactivity.en_US
dc.description.sponsorshipThe authors gratefully acknowledge Areka Advanced Technologies LLC for the lab-scale centrifugal spinning system.en_US
dc.identifier.doi10.1088/2631-6331/ad5b49
dc.identifier.issn2631-6331
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85198005496en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1088/2631-6331/ad5b49
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5895
dc.identifier.volume6en_US
dc.identifier.wosWOS:001261101700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIop Publishing Ltden_US
dc.relation.ispartofFunctional Composites and Structuresen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcentrifugal spinningen_US
dc.subjectcarbon nanofiberen_US
dc.subjecthydroxyapatiteen_US
dc.subjectbioactivityen_US
dc.titleCentrifugally spun hydroxyapatite/carbon composite nanofiber scaffolds for bone tissue engineeringen_US
dc.typeArticleen_US

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