Cytotoxic effects, microbiological analysis and inhibitory properties on carbonic anhydrase isozyme activities of 2-hydroxy-5-methoxyacetophenone thiosemicarbazone and its Cu(II), Co(II), Zn(II) and Mn(II) complexes

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dc.authoridSayin, Ulku/0000-0002-5098-1578
dc.authoridSayin, Zafer/0000-0001-6096-4440
dc.authoridPehlivanoglu, Suray/0000-0001-7422-2974
dc.contributor.authorUcar, Asuman
dc.contributor.authorFindik, Mukerrem
dc.contributor.authorKuzu, Muslum
dc.contributor.authorPehlivanoglu, Suray
dc.contributor.authorSayin, Ulku
dc.contributor.authorSayin, Zafer
dc.contributor.authorAkgemci, Emine Guler
dc.date.accessioned2024-09-29T15:51:25Z
dc.date.available2024-09-29T15:51:25Z
dc.date.issued2021
dc.departmentKarabük Üniversitesien_US
dc.description.abstractMetal complexes of thiosemicarbazones have been receiving considerable attention in biological applications such as antimicrobial and anticancer therapies. In this work, Co(II), Zn(II) and Mn(II) complexes of 2-hydroxy-5-methoxyacetophenone thiosemicarbazone (HMAT) were synthesized for the first time and characterized by EPR, FT-IR, NMR, UV-Vis spectroscopies, TG/DSC and elemental analysis. X-ray powder diffraction analysis was carried out for Zn(II) complex. HMAT and its Cu(II), Co(II), Zn(II) and Mn(II) complexes were tested as enzyme inhibitory agents. All compounds are effective inhibitor of cytosolic carbonic anhydrase I and II isoforms (hCA I and II) enzymes. IC(50)values of HMAT and its Cu(II), Co(II), Zn(II) and Mn(II) complexes were determined as 93.35, 324.46, 25.67, 1.06 and 22.36 mu M for CA I isozyme and 99.02, 86.64, 57.76, 10.34 and 36.48 mu M for CA II isozyme, respectively. The evaluation of potential cytotoxic effects of the compounds was performed against normal epithelial breast mammary gland CRL-4010, estrogen-positive low metastatic MCF-7 and triple negative highly metastatic MDA-MB-231 breast adenocarcinoma cell lines by MTT assay. The results showed that the tested metal complexes have high cytotoxic effects than their ligand molecule. In particular, the Cu(II) complex displayed preciously high cytotoxic properties different from the others. Given these facts, the Cu(II) complex could be debated as potential chemotherapeutic molecule against drug-resistant breast cancer cells. Minimum inhibitory concentrations of the compounds against the test organisms were also detected for the microbiological analysis.en_US
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Foundation [BAP-161715001]en_US
dc.description.sponsorshipThis study was supported by the Necmettin Erbakan University Scientific Research Foundation (BAP-161715001)en_US
dc.identifier.doi10.1007/s11164-020-04284-8
dc.identifier.endpage550en_US
dc.identifier.issn0922-6168
dc.identifier.issn1568-5675
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85092231648en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage533en_US
dc.identifier.urihttps://doi.org/10.1007/s11164-020-04284-8
dc.identifier.urihttps://hdl.handle.net/20.500.14619/4062
dc.identifier.volume47en_US
dc.identifier.wosWOS:000577365400002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofResearch On Chemical Intermediatesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThiosemicarbazoneen_US
dc.subjectComplexesen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectAntimicrobial and anticancer activityen_US
dc.subjectSpectroscopic and thermal analysisen_US
dc.titleCytotoxic effects, microbiological analysis and inhibitory properties on carbonic anhydrase isozyme activities of 2-hydroxy-5-methoxyacetophenone thiosemicarbazone and its Cu(II), Co(II), Zn(II) and Mn(II) complexesen_US
dc.typeArticleen_US

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