Genetic and environmental etiology of drinking motives in college students

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dc.authoridSavage, Jeanne/0000-0002-2034-8341
dc.authoridDick, Danielle/0000-0002-1636-893X
dc.contributor.authorSavage, Jeanne E.
dc.contributor.authorPeterson, Roseann E.
dc.contributor.authorAliev, Fazil
dc.contributor.authorDick, Danielle M.
dc.date.accessioned2024-09-29T16:04:33Z
dc.date.available2024-09-29T16:04:33Z
dc.date.issued2022
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground Drinking motives are robust proximal predictors of alcohol use behaviors and may mediate distinct etiological pathways in the development of alcohol misuse. However, little is known about the genetic and environmental etiology of drinking motives themselves and their potential utility as endophenotypes. Methods Here, we leverage a longitudinal study of college students from diverse racial/ethnic backgrounds (phenotypic N = 9889, genotypic N = 4855) to investigate the temporal stability and demographic and environmental predictors of four types of drinking motives (enhancement, social, coping, and conformity). Using genome-wide association study (GWAS) and in silico tools, we characterize their associated genes and genetic variants (single nucleotide polymorphisms or SNPs). Results Drinking motives were stable across four years of college (ICC >0.74). Some robust environmental predictors of alcohol misuse (parental autonomy granting and peer deviance) were broadly associated with multiple types of drinking motives, while others (e.g., trauma exposure) were type specific. Genome-wide analyses indicated modest SNP-based heritability (14-22%, n.s.) and several suggestive genomic loci that corroborate findings from previous molecular genetic studies (e.g., PECR and SIRT4 genes), indicating possible differences in the genetic etiology of positive versus negative reinforcement drinking motives that align with an internalizing/externalizing typology of alcohol misuse. Coping motives were significantly genetically correlated with alcohol use disorder diagnoses (r(g) = 0.71, p = 0.001). However, results from the genetic analyses were largely underpowered to detect significant associations. Conclusions Drinking motives show promise as endophenotypes but require further investigation in larger samples to further our understanding of the etiology of alcohol misuse.en_US
dc.description.sponsorshipBrain and Behavior Research Foundation; Center for Tobacco Products; National Alliance for Research on Schizophrenia and Depression [28632]; National Center for Research Resources [UL1RR031990]; National Institute of Mental Health [K01MH113848]; National Institute on Alcohol Abuse and Alcoholism [F31AA024378, K01AA024152, K02AA018755, P20AA017828, P50AA022537, R37AA011408]; National Institute on Drug Abuse [U54DA036105]; National Institutes of Health; Virginia Commonwealth University; National Institute on Alcohol Abuse and Alcoholism [P50AA022537] Funding Source: NIH RePORTER; NIH Office of the Director [U54DA036105] Funding Source: NIH RePORTERen_US
dc.description.sponsorshipBrain and Behavior Research Foundation; Center for Tobacco Products; National Alliance for Research on Schizophrenia and Depression, Grant/Award Number: 28632; National Center for Research Resources, Grant/Award Number: UL1RR031990; National Institute of Mental Health, Grant/Award Number: K01MH113848; National Institute on Alcohol Abuse and Alcoholism, Grant/Award Number: F31AA024378, K01AA024152, K02AA018755, P20AA017828, P50AA022537 and R37AA011408; National Institute on Drug Abuse, Grant/Award Number: U54DA036105; National Institutes of Health, Grant/Award Number: Roadmap for Medical Research; Virginia Commonwealth Universityen_US
dc.identifier.doi10.1111/acer.14930
dc.identifier.endpage1796en_US
dc.identifier.issn2993-7175
dc.identifier.issue10en_US
dc.identifier.pmid36256465en_US
dc.identifier.scopus2-s2.0-85139986573en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1783en_US
dc.identifier.urihttps://doi.org/10.1111/acer.14930
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6200
dc.identifier.volume46en_US
dc.identifier.wosWOS:000869171100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAlcohol-Clinical and Experimental Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectalcohol misuseen_US
dc.subjectcollege studentsen_US
dc.subjectdrinking motivesen_US
dc.subjectendophenotypeen_US
dc.subjectGWASen_US
dc.titleGenetic and environmental etiology of drinking motives in college studentsen_US
dc.typeArticleen_US

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