Genetic and environmental etiology of drinking motives in college students
dc.authorid | Savage, Jeanne/0000-0002-2034-8341 | |
dc.authorid | Dick, Danielle/0000-0002-1636-893X | |
dc.contributor.author | Savage, Jeanne E. | |
dc.contributor.author | Peterson, Roseann E. | |
dc.contributor.author | Aliev, Fazil | |
dc.contributor.author | Dick, Danielle M. | |
dc.date.accessioned | 2024-09-29T16:04:33Z | |
dc.date.available | 2024-09-29T16:04:33Z | |
dc.date.issued | 2022 | |
dc.department | Karabük Üniversitesi | en_US |
dc.description.abstract | Background Drinking motives are robust proximal predictors of alcohol use behaviors and may mediate distinct etiological pathways in the development of alcohol misuse. However, little is known about the genetic and environmental etiology of drinking motives themselves and their potential utility as endophenotypes. Methods Here, we leverage a longitudinal study of college students from diverse racial/ethnic backgrounds (phenotypic N = 9889, genotypic N = 4855) to investigate the temporal stability and demographic and environmental predictors of four types of drinking motives (enhancement, social, coping, and conformity). Using genome-wide association study (GWAS) and in silico tools, we characterize their associated genes and genetic variants (single nucleotide polymorphisms or SNPs). Results Drinking motives were stable across four years of college (ICC >0.74). Some robust environmental predictors of alcohol misuse (parental autonomy granting and peer deviance) were broadly associated with multiple types of drinking motives, while others (e.g., trauma exposure) were type specific. Genome-wide analyses indicated modest SNP-based heritability (14-22%, n.s.) and several suggestive genomic loci that corroborate findings from previous molecular genetic studies (e.g., PECR and SIRT4 genes), indicating possible differences in the genetic etiology of positive versus negative reinforcement drinking motives that align with an internalizing/externalizing typology of alcohol misuse. Coping motives were significantly genetically correlated with alcohol use disorder diagnoses (r(g) = 0.71, p = 0.001). However, results from the genetic analyses were largely underpowered to detect significant associations. Conclusions Drinking motives show promise as endophenotypes but require further investigation in larger samples to further our understanding of the etiology of alcohol misuse. | en_US |
dc.description.sponsorship | Brain and Behavior Research Foundation; Center for Tobacco Products; National Alliance for Research on Schizophrenia and Depression [28632]; National Center for Research Resources [UL1RR031990]; National Institute of Mental Health [K01MH113848]; National Institute on Alcohol Abuse and Alcoholism [F31AA024378, K01AA024152, K02AA018755, P20AA017828, P50AA022537, R37AA011408]; National Institute on Drug Abuse [U54DA036105]; National Institutes of Health; Virginia Commonwealth University; National Institute on Alcohol Abuse and Alcoholism [P50AA022537] Funding Source: NIH RePORTER; NIH Office of the Director [U54DA036105] Funding Source: NIH RePORTER | en_US |
dc.description.sponsorship | Brain and Behavior Research Foundation; Center for Tobacco Products; National Alliance for Research on Schizophrenia and Depression, Grant/Award Number: 28632; National Center for Research Resources, Grant/Award Number: UL1RR031990; National Institute of Mental Health, Grant/Award Number: K01MH113848; National Institute on Alcohol Abuse and Alcoholism, Grant/Award Number: F31AA024378, K01AA024152, K02AA018755, P20AA017828, P50AA022537 and R37AA011408; National Institute on Drug Abuse, Grant/Award Number: U54DA036105; National Institutes of Health, Grant/Award Number: Roadmap for Medical Research; Virginia Commonwealth University | en_US |
dc.identifier.doi | 10.1111/acer.14930 | |
dc.identifier.endpage | 1796 | en_US |
dc.identifier.issn | 2993-7175 | |
dc.identifier.issue | 10 | en_US |
dc.identifier.pmid | 36256465 | en_US |
dc.identifier.scopus | 2-s2.0-85139986573 | en_US |
dc.identifier.scopusquality | N/A | en_US |
dc.identifier.startpage | 1783 | en_US |
dc.identifier.uri | https://doi.org/10.1111/acer.14930 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14619/6200 | |
dc.identifier.volume | 46 | en_US |
dc.identifier.wos | WOS:000869171100001 | en_US |
dc.identifier.wosquality | N/A | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.relation.ispartof | Alcohol-Clinical and Experimental Research | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | alcohol misuse | en_US |
dc.subject | college students | en_US |
dc.subject | drinking motives | en_US |
dc.subject | endophenotype | en_US |
dc.subject | GWAS | en_US |
dc.title | Genetic and environmental etiology of drinking motives in college students | en_US |
dc.type | Article | en_US |