Enzyme Inhibition and Antioxidant Activities of Asparagus officinalis L. and Analysis of Its Phytochemical Content by LC/MS/MS

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dc.authoridAYDIN, TUBA/0000-0002-7653-6480
dc.authoridKaragoz, Yalcin/0000-0002-4835-4508
dc.contributor.authorComakli, Veysel
dc.contributor.authorSaglamtas, Rueya
dc.contributor.authorKuzu, Muslum
dc.contributor.authorKaragoz, Yalcin
dc.contributor.authorAydin, Tuba
dc.contributor.authorDemirdag, Ramazan
dc.date.accessioned2024-09-29T15:50:38Z
dc.date.available2024-09-29T15:50:38Z
dc.date.issued2023
dc.departmentKarabük Üniversitesien_US
dc.description.abstractIn the study, water, ethanol, methanol, dichloromethane, and acetone extracts of Asparagus officinalis L. were obtained by maceration. DPPH*, ABTS(*+), FRAP, and CUPRAC methods determined the antioxidant capacities of all extracts. Moreover, the in vitro effects of extracts on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase (CA)-I, CA-II and a-Glycosidase were investigated. At a 10 mu g/ml concentration, the extract with the highest Fe3+ reduction capacity was ethanol (AE), and the extract with the highest Cu2+ reduction capacity was acetone (AA). AE for AChE (IC50= 21.19 mu g/ml) and a-Glycosidase (IC50: 70.00 mu g/ml), methanol (AM) for BChE (IC50= 17.33 mu g/ml), CA I and II (IC50= 79.65 and 36.09 mu g/ml, respectively) showed the most potent inhibition effect. The content analysis of acetone extract was performed with LC/MS-MS, the first three phytochemicals found most were p-Coumaric acid, rutin, and 4-hydroxybenzoic acid (284.29 +/- 3.97, 135.39 +/- 8.19, and 102.06 +/- 5.51 mu g analyte/g extract, respectively).en_US
dc.identifier.doi10.1002/cbdv.202201231
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue5en_US
dc.identifier.pmid37096958en_US
dc.identifier.scopus2-s2.0-85153333091en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/cbdv.202201231
dc.identifier.urihttps://hdl.handle.net/20.500.14619/3650
dc.identifier.volume20en_US
dc.identifier.wosWOS:000978619200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistry & Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectasparagus officinalisen_US
dc.subjectcholinesteraseen_US
dc.subjectcarbonicen_US
dc.subjectanhydraseen_US
dc.subjecta-glycosidaseen_US
dc.subjectinhibitionen_US
dc.titleEnzyme Inhibition and Antioxidant Activities of Asparagus officinalis L. and Analysis of Its Phytochemical Content by LC/MS/MSen_US
dc.typeArticleen_US

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